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We provide a short supplement to the paper MAPK networks and their capacity for multistationarity due to toric steady states by Perez Millan and Turjanski. We show that the capacity for toric steady states in the three networks analyzed in that paper can be derived using the process of network translation, which corresponds the original mass action system to a generalized mass action system with the same steady states. In all three cases, the translated chemical reaction network is proper, weakly reversible, and has both a structural and kinetic deficiency of zero. This is sufficient to guarantee toric steady states by previously established work on network translations. A basis of the steady state ideal is then derived by consideration of the linkage classes of the translated chemical reaction network.
The multisite phosphorylation-dephosphorylation cycle is a motif repeatedly used in cell signaling. This motif itself can generate a variety of dynamic behaviors like bistability and ultrasensitivity without direct positive feedbacks. In this paper,
We derive a reduction formula for singularly perturbed ordinary differential equations (in the sense of Tikhonov and Fenichel) with a known parameterization of the critical manifold. No a priori assumptions concerning separation of slow and fast vari
The goal of this paper is to gather and develop some necessary and sufficient criteria for injectivity and multistationarity in vector fields associated with a chemical reaction network under a variety of more or less general assumptions on the natur
We study two specific measures of quality of chemical reaction networks, Precision and Sensitivity. The two measures arise in the study of sensory adaptation, in which the reaction network is viewed as an input-output system. Given a step change in i
We are concerned with polynomial ordinary differential systems that arise from modelling chemical reaction networks. For such systems, which may be of high dimension and may depend on many parameters, it is frequently of interest to obtain a reductio