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Population genetics of neutral mutations in exponentially growing cancer cell populations

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 نشر من قبل Rick Durrett
 تاريخ النشر 2013
  مجال البحث علم الأحياء
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 تأليف Rick Durrett




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In order to analyze data from cancer genome sequencing projects, we need to be able to distinguish causative, or driver, mutations from passenger mutations that have no selective effect. Toward this end, we prove results concerning the frequency of neutural mutations in exponentially growing multitype branching processes that have been widely used in cancer modeling. Our results yield a simple new population genetics result for the site frequency spectrum of a sample from an exponentially growing population.



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