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Tug-of-war of molecular motors: the effects of uneven load sharing

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 نشر من قبل Fernando Falo
 تاريخ النشر 2011
  مجال البحث فيزياء علم الأحياء
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 تأليف Sebastian Bouzat




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We analyze theoretically the problem of cargo transport along microtubules by motors of two species with opposite polarities. We consider two different one-dimensional models previously developed in the literature. On the one hand, a quite widespread model which assumes equal force sharing, here referred to as mean field model (MFM). On the other hand, a stochastic model (SM) which considers individual motor-cargo links. We find that in generic situations the MFM predicts larger cargo mean velocity, smaller mean run time and less frequent



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