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We introduce the software tool NTRFinder to find the complex repetitive structure in DNA we call a nested tandem repeat (NTR). An NTR is a recurrence of two or more distinct tandem motifs interspersed with each other. We propose that nested tandem repeats can be used as phylogenetic and population markers. We have tested our algorithm on both real and simulated data, and present some real nested tandem repeats of interest. We discuss how the NTR found in the ribosomal DNA of taro (Colocasia esculenta) may assist in determining the cultivation prehistory of this ancient staple food crop. NTRFinder can be downloaded from http://www.maths.otago.ac.nz/? aamatroud/.
We propose a simple tractable pair hidden Markov model for pairwise sequence alignment that accounts for the presence of short tandem repeats. Using the framework of gain functions, we design several optimization criteria for decoding this model and
Untargeted metabolomic studies are revealing large numbers of naturally occurring metabolites that cannot be characterized because their chemical structures and MS/MS spectra are not available in databases. Here we present iMet, a computational tool
Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now readily ava
Because of the recent technological advances, the key technologies needed for precision space optical astrometry are now in hand. The Microarcsecond Astrometry Probe (MAP) mission concept is designed to find 1 Earth mass planets at 1AU orbit (scaled
Metabarcoding on amplicons is rapidly expanding as a method to produce molecular based inventories of microbial communities. Here, we work on freshwater diatoms, which are microalgae possibly inventoried both on a morphological and a molecular basis.