ترغب بنشر مسار تعليمي؟ اضغط هنا

The information capacity of hypercycles

108   0   0.0 ( 0 )
 نشر من قبل Daniel Silvestre
 تاريخ النشر 2008
  مجال البحث علم الأحياء
والبحث باللغة English




اسأل ChatGPT حول البحث

Hypercycles are information integration systems which are thought to overcome the information crisis of prebiotic evolution by ensuring the coexistence of several short templates. For imperfect template replication, we derive a simple expression for the maximum number of distinct templates $n_m$ that can coexist in a hypercycle and show that it is a decreasing function of the length $L$ of the templates. In the case of high replication accuracy we find that the product $n_m L$ tends to a constant value, limiting thus the information content of the hypercycle. Template coexistence is achieved either as a stationary equilibrium (stable fixed point) or a stable periodic orbit in which the total concentration of functional templates is nonzero. For the hypercycle system studied here we find numerical evidence that the existence of an unstable fixed point is a necessary condition for the presence of periodic orbits.



قيم البحث

اقرأ أيضاً

Cancer cells are known to modify their micro-environment such that it can sustain a larger population, or, in ecological terms, they construct a niche which increases the carrying capacity of the population. It has however been argued that niche cons truction, which benefits all cells in the tumour, would be selected against since cheaters could reap the benefits without paying the cost. We have investigated the impact of niche specificity on tumour evolution using an individual based model of breast tumour growth, in which the carrying capacity of each cell consists of two components: an intrinsic, subclone-specific part and a contribution from all neighbouring cells. Analysis of the model shows that the ability of a mutant to invade a resident population depends strongly on the specificity. When specificity is low selection is mostly on growth rate, while high specificity shifts selection towards increased carrying capacity. Further, we show that the long-term evolution of the system can be predicted using adaptive dynamics. By comparing the results from a spatially structured vs. well-mixed population we show that spatial structure restores selection for carrying capacity even at zero specificity, which a poses solution to the niche construction dilemma. Lastly, we show that an expanding population exhibits spatially variable selection pressure, where cells at the leading edge exhibit higher growth rate and lower carrying capacity than those at the centre of the tumour.
79 - Jurgen Jost 2020
In computer science, we can theoretically neatly separate transmission and processing of information, hardware and software, and programs and their inputs. This is much more intricate in biology, Nevertheless, I argue that Shannons concept of informa tion is useful in biology, although its application is not as straightforward as many people think. In fact, the recently developed theory of information decomposition can shed much light on the complementarity between coding and regulatory, or internal and environmental information. The key challenge that we formulate in this contribution is to understand how genetic information and external factors combine to create an organism, and conversely, how the genome has learned in the course of evolution how to harness the environment, and analogously, how coding, regulation and spatial organization interact in cellular processes.
The coexistence between different types of templates has been the choice solution to the information crisis of prebiotic evolution, triggered by the finding that a single RNA-like template cannot carry enough information to code for any useful replic ase. In principle, confining $d$ distinct templates of length $L$ in a package or protocell, whose survival depends on the coexistence of the templates it holds in, could resolve this crisis provided that $d$ is made sufficiently large. Here we review the prototypical package model of Niesert et al. 1981 which guarantees the greatest possible region of viability of the protocell population, and show that this model, and hence the entire package approach, does not resolve the information crisis. This is so because to secure survival the total information content of the protocell, $Ld$, must tend to a constant value that depends only on the spontaneous error rate per nucleotide of the template replication mechanism. As a result, an increase of $d$ must be followed by a decrease of $L$ to ensure the protocell viability, so that the net information gain is null.
We estimate the growth in demand for ICU beds in Chicago during the emerging COVID-19 epidemic, using state-of-the-art computer simulations calibrated for the SARS-CoV-2 virus. The questions we address are these: (1) Will the ICU capacity in Chicag o be exceeded, and if so by how much? (2) Can strong mitigation strategies, such as lockdown or shelter in place order, prevent the overflow of capacity? (3) When should such strategies be implemented? Our answers are as follows: (1) The ICU capacity may be exceeded by a large amount, probably by a factor of ten. (2) Strong mitigation can avert this emergency situation potentially, but even that will not work if implemented too late. (3) If the strong mitigation precedes April 1st, then the growth of COVID-19 can be controlled and the ICU capacity could be adequate. The earlier the strong mitigation is implemented, the greater the probability that it will be successful. After around April 1 2020, any strong mitigation will not avert the emergency situation. In Italy, the lockdown occurred too late and the number of deaths is still doubling every 2.3 days. It is difficult to be sure about the precise dates for this window of opportunity, due to the inherent uncertainties in computer simulation. But there is high confidence in the main conclusion that it exists and will soon be closed. Our conclusion is that, being fully cognizant of the societal trade-offs, there is a rapidly closing window of opportunity to avert a worst-case scenario in Chicago, but only with strong mitigation/lockdown implemented in the next week at the latest. If this window is missed, the epidemic will get worse and then strong mitigation/lockdown will be required after all, but it will be too late.
Cooperators forgo their interest to benefit others. Thus cooperation should not be favored by natural selection. It challenges the evolutionists, since cooperation is widespread. As one of the resolutions, information spreading has been revealed to p lay a key role in the emergence of cooperation. Individuals, however, are typically assumed to be passive in the information spreading. Here we assume that individuals are active to spread the information via self-recommendation. Individuals with higher intensities of self-recommendation are likely to have more neighbors. We find that i) eloquent cooperators are necessary to promote cooperation; ii) individuals need to be open to the self-recommendation to enhance cooperation level; iii) the cost-to-benefit ratio should be smaller than one minus the ratio between self-recommendation intensities of defector and cooperator, which qualitatively measures the viscosity of the population. Our results highlight the importance of active information spreading on cooperation.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا