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تسجيل مستخدم جديدNetwork Structure and Dynamics, and Emergence of Robustness by Stabilizing Selection in an Artificial Genome
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Genetic regulation is a key component in development, but a clear understanding of the structure and dynamics of genetic networks is not yet at hand. In this work we investigate these properties within an artificial genome model originally introduced by Reil. We analyze statistical properties of randomly generated genomes both on the sequence- and network level, and show that this model correctly predicts the frequency of genes in genomes as found in experimental data. Using an evolutionary algorithm based on stabilizing selection for a phenotype, we show that robustness against single base mutations, as well as against random changes in initial network states that mimic stochastic fluctuations in environmental conditions, can emerge in parallel. Evolved genomes exhibit characteristic patterns on both sequence and network level.
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Genetic regulation is a key component in development, but a clear understanding of the structure and dynamics of genetic networks is not yet at hand. In this paper we investigate these properties within an artificial genome model originally introduce
d by Reil (1999). We analyze statistical properties of randomly generated genomes both on the sequence- and network level, and show that this model correctly predicts the frequency of genes in genomes as found in experimental data. Using an evolutionary algorithm based on stabilizing selection for a phenotype, we show that dynamical robustness against single base mutations, as well as against random changes in initial states of regulatory dynamics that mimic stochastic fluctuations in environmental conditions, can emerge in parallel. Point mutations at the sequence level have strongly non-linear effects on network wiring, including as well structurally neutral mutations and simultaneous rewiring of multiple connections, which occasionally lead to strong reorganization of the attractor landscape and metastability of evolutionary dynamics. Evolved genomes exhibit characteristic patterns on both sequence and network level.
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