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The COVID-19 pandemic has demonstrated how disruptive emergent disease outbreaks can be and how useful epidemic models are for quantifying risks of local outbreaks. Here we develop an analytical approach to calculate the dynamics and likelihood of outbreaks within the canonical Susceptible-Exposed-Infected-Recovered and more general models, including COVID-19 models, with fixed population sizes. We compute the distribution of outbreak sizes including extreme events, and show that each outbreak entails a unique, depletion or boost in the pool of susceptibles and an increase or decrease in the effective recovery rate compared to the mean-field dynamics -- due to finite-size noise. Unlike extreme events occurring in long-lived metastable stochastic systems, the underlying outbreak distribution depends on a full continuum of optimal paths, each connecting two unique non-trivial fixed-points, and thus represents a novel class of extreme dynamics.
We calculate both the exponential and pre-factor contributions in a WKB approximation of the master equation for a stochastic SIR model with highly oscillatory dynamics. Fixing the basic parameters of the model we investigate how the outbreak distrib
Understanding and predicting outbreaks of contagious diseases are crucial to the development of society and public health, especially for underdeveloped countries. However, challenging problems are encountered because of complex epidemic spreading dy
Background: A deterministic model is developed for the spatial spread of an epidemic disease in a geographical setting. The disease is borne by vectors to susceptible hosts through criss-cross dynamics. The model is focused on an epidemic outbreak th
This article contains a series of analyses done for the SARS-CoV-2 outbreak in Rio Grande do Sul (RS) in the south of Brazil. These analyses are focused on the high-incidence cities such as the state capital Porto Alegre and at the state level. We pr
In times of outbreaks, an essential requirement for better monitoring is the evaluation of the number of undiagnosed infected individuals. An accurate estimate of this fraction is crucial for the assessment of the situation and the establishment of p