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تسجيل مستخدم جديدMutation timing in a spatial model of evolution
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Motivated by models of cancer formation in which cells need to acquire $k$ mutations to become cancerous, we consider a spatial population model in which the population is represented by the $d$-dimensional torus of side length $L$. Initially, no sites have mutations, but sites with $i-1$ mutations acquire an $i$th mutation at rate $mu_i$ per unit area. Mutations spread to neighboring sites at rate $alpha$, so that $t$ time units after a mutation, the region of individuals that have acquired the mutation will be a ball of radius $alpha t$. We calculate, for some ranges of the parameter values, the asymptotic distribution of the time required for some individual to acquire $k$ mutations. Our results, which build on previous work of Durrett, Foo, and Leder, are essentially complete when $k = 2$ and when $mu_i = mu$ for all $i$.
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We consider a spatial model of cancer in which cells are points on the $d$-dimensional torus $mathcal{T}=[0,L]^d$, and each cell with $k-1$ mutations acquires a $k$th mutation at rate $mu_k$. We will assume that the mutation rates $mu_k$ are increasi
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