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Fields like public health, public policy, and social science often want to quantify the degree of dependence between variables whose relationships take on unknown functional forms. Typically, in fact, researchers in these fields are attempting to evaluate causal theories, and so want to quantify dependence after conditioning on other variables that might explain, mediate or confound causal relations. One reason conditional mutual information is not more widely used for these tasks is the lack of estimators which can handle combinations of continuous and discrete random variables, common in applications. This paper develops a new method for estimating mutual and conditional mutual information for data samples containing a mix of discrete and continuous variables. We prove that this estimator is consistent and show, via simulation, that it is more accurate than similar estimators.
Nonparametric estimation of mutual information is used in a wide range of scientific problems to quantify dependence between variables. The k-nearest neighbor (knn) methods are consistent, and therefore expected to work well for large sample size. Th
We develop a Nonparametric Empirical Bayes (NEB) framework for compound estimation in the discrete linear exponential family, which includes a wide class of discrete distributions frequently arising from modern big data applications. We propose to di
This paper studies the generalization of the targeted minimum loss-based estimation (TMLE) framework to estimation of effects of time-varying interventions in settings where both interventions, covariates, and outcome can happen at subject-specific t
We study a functional linear regression model that deals with functional responses and allows for both functional covariates and high-dimensional vector covariates. The proposed model is flexible and nests several functional regression models in the
Selective recruitment designs preferentially recruit individuals that are estimated to be statistically informative onto a clinical trial. Individuals that are expected to contribute less information have a lower probability of recruitment. Furthermo