We present the first direct lattice calculation of the isovector sea-quark parton distributions using the formalism developed recently by one of the authors. We use $N_f=2+1+1$ HISQ lattice gauge ensembles (generated by MILC Collaboration) and clover
valence fermions with pion mass 310 MeV. We are able to obtain the qualitative features of the nucleon sea flavor structure even at this large pion mass: We observe violation of the Gottfried sum rule, indicating $overline{d}(x) > overline{u}(x)$; the helicity distribution obeys $Delta overline{u}(x) > Delta overline{d}(x)$, which is consistent with the STAR data at large and small leptonic pseudorapidity.
