We report theoretical and experimental studies of the effect of Zn-impurity in Fe-based superconductors. Zn-impurity is expected to severely suppress sign reversed s$_pm$ wave pairing. The experimentally observed suppression of T$_c$ under Zn-doping
strongly depends on the materials and the charge carrier contents, which suggests competition of $s_{++}$ and $s_{pm}$ pairings in Fe-base superconductors. We study a model incorporating both $s_{++}$ and $s_{pm}$ pairing couplings by using Bogoliubov de-Gennes equation, and show that the Zn-impurity strongly suppresses $s_{pm}$ pairing and may induce a transition from $s_{pm}$ to $s_{++}$-wave. Our theory is consistent with various experiments on the impurity effect. We present new experimental data on the Zn-doping SmFe$_{1-x}$Zn$_x$AsO$_{0.9}$F$_{0.1}$ of T$_c=$ 50K, in further support of our proposal.
