When no arterial input function is available, quantification of dynamic PET images requires a previous step devoted to the extraction of a reference time-activity curve (TAC). Factor analysis is often applied for this purpose. This paper introduces a
novel approach that conducts a new kind of nonlinear factor analysis relying on a compartment model, and computes the kinetic parameters of specific binding tissues jointly. To this end, it capitalizes on data-driven parametric imaging methods to provide a physical description of the underlying PET data, directly relating the specific binding with the kinetics of the non-specific binding in the corresponding tissues. This characterization is introduced into the factor analysis formulation to yield a novel nonlinear unmixing model designed for PET image analysis. This model also explicitly introduces global kinetic parameters that allow for a direct estimation of the binding potential with respect to the free fractions in each non-specific binding tissue. The performance of the method is evaluated on synthetic and real data to demonstrate its potential interest.
Archetypal scenarios for change detection generally consider two images acquired through sensors of the same modality. However, in some specific cases such as emergency situations, the only images available may be those acquired through sensors of di
fferent modalities. This paper addresses the problem of unsupervisedly detecting changes between two observed images acquired by sensors of different modalities with possibly different resolutions. These sensor dissimilarities introduce additional issues in the context of operational change detection that are not addressed by most of the classical methods. This paper introduces a novel framework to effectively exploit the available information by modelling the two observed images as a sparse linear combination of atoms belonging to a pair of coupled overcomplete dictionaries learnt from each observed image. As they cover the same geographical location, codes are expected to be globally similar, except for possible changes in sparse spatial locations. Thus, the change detection task is envisioned through a dual code estimation which enforces spatial sparsity in the difference between the estimated codes associated with each image. This problem is formulated as an inverse problem which is iteratively solved using an efficient proximal alternating minimization algorithm accounting for nonsmooth and nonconvex functions. The proposed method is applied to real images with simulated yet realistic and real changes. A comparison with state-of-the-art change detection methods evidences the accuracy of the proposed strategy.
