SIHR: An R Package for Statistical Inference in High-dimensional Linear and Logistic Regression Models

We introduce and illustrate through numerical examples the R package texttt{SIHR} which handles the statistical inference for (1) linear and quadratic functionals in the high-dimensional linear regression and (2) linear functional in the high-dimensional logistic regression. The focus of the proposed algorithms is on the point estimation, confidence interval construction and hypothesis testing. The inference methods are extended to multiple regression models. We include real data applications to demonstrate the packages performance and practicality.

Theoretical Foundations of t-SNE for Visualizing High-Dimensional Clustered Data

This study investigates the theoretical foundations of t-distributed stochastic neighbor embedding (t-SNE), a popular nonlinear dimension reduction and data visualization method. A novel theoretical framework for the analysis of t-SNE based on the gradient descent approach is presented. For the early exaggeration stage of t-SNE, we show its asymptotic equivalence to a power iteration based on the underlying graph Laplacian, characterize its limiting behavior, and uncover its deep connection to Laplacian spectral clustering, and fundamental principles including early stopping as implicit regularization. The results explain the intrinsic mechanism and the empirical benefits of such a computational strategy. For the embedding stage of t-SNE, we characterize the kinematics of the low-dimensional map throughout the iterations, and identify an amplification phase, featuring the intercluster repulsion and the expansive behavior of the low-dimensional map. The general theory explains the fast convergence rate and the exceptional empirical performance of t-SNE for visualizing clustered data, brings forth the interpretations of the t-SNE output, and provides theoretical guidance for selecting tuning parameters in various applications.

Transfer Learning in Large-scale Gaussian Graphical Models with False Discovery Rate Control

Transfer learning for high-dimensional Gaussian graphical models (GGMs) is studied with the goal of estimating the target GGM by utilizing the data from similar and related auxiliary studies. The similarity between the target graph and each auxiliary graph is characterized by the sparsity of a divergence matrix. An estimation algorithm, Trans-CLIME, is proposed and shown to attain a faster convergence rate than the minimax rate in the single study setting. Furthermore, a debiased Trans-CLIME estimator is introduced and shown to be element-wise asymptotically normal. It is used to construct a multiple testing procedure for edge detection with false discovery rate control. The proposed estimation and multiple testing procedures demonstrate superior numerical performance in simulations and are applied to infer the gene networks in a target brain tissue by leveraging the gene expressions from multiple other brain tissues. A significant decrease in prediction errors and a significant increase in power for link detection are observed.

Transfer Learning for High-dimensional Linear Regression: Prediction, Estimation, and Minimax Optimality

This paper considers the estimation and prediction of a high-dimensional linear regression in the setting of transfer learning, using samples from the target model as well as auxiliary samples from different but possibly related regression models. When the set of informative auxiliary samples is known, an estimator and a predictor are proposed and their optimality is established. The optimal rates of convergence for prediction and estimation are faster than the corresponding rates without using the auxiliary samples. This implies that knowledge from the informative auxiliary samples can be transferred to improve the learning performance of the target problem. In the case that the set of informative auxiliary samples is unknown, we propose a data-driven procedure for transfer learning, called Trans-Lasso, and reveal its robustness to non-informative auxiliary samples and its efficiency in knowledge transfer. The proposed procedures are demonstrated in numerical studies and are applied to a dataset concerning the associations among gene expressions. It is shown that Trans-Lasso leads to improved performance in gene expression prediction in a target tissue by incorporating the data from multiple different tissues as auxiliary samples.

Sparse Group Lasso: Optimal Sample Complexity, Convergence Rate, and Statistical Inference

In this paper, we study sparse group Lasso for high-dimensional double sparse linear regression, where the parameter of interest is simultaneously element-wise and group-wise sparse. This problem is an important instance of the simultaneously structured model -- an actively studied topic in statistics and machine learning. In the noiseless case, we provide matching upper and lower bounds on sample complexity for the exact recovery of sparse vectors and for stable estimation of approximately sparse vectors, respectively. In the noisy case, we develop upper and matching minimax lower bounds for estimation error. We also consider the debiased sparse group Lasso and investigate its asymptotic property for the purpose of statistical inference. Finally, numerical studies are provided to support the theoretical results.

Asymptotic Analysis for Extreme Eigenvalues of Principal Minors of Random Matrices

Consider a standard white Wishart matrix with parameters $n$ and $p$. Motivated by applications in high-dimensional statistics and signal processing, we perform asymptotic analysis on the maxima and minima of the eigenvalues of all the $m times m$ principal minors, under the asymptotic regime that $n,p,m$ go to infinity. Asymptotic results concerning extreme eigenvalues of principal minors of real Wigner matrices are also obtained. In addition, we discuss an application of the theoretical results to the construction of compressed sensing matrices, which provides insights to compressed sensing in signal processing and high dimensional linear regression in statistics.

Limiting Laws for Divergent Spiked Eigenvalues and Largest Non-spiked Eigenvalue of Sample Covariance Matrices

We study the asymptotic distributions of the spiked eigenvalues and the largest nonspiked eigenvalue of the sample covariance matrix under a general covariance matrix model with divergent spiked eigenvalues, while the other eigenvalues are bounded but otherwise arbitrary. The limiting normal distribution for the spiked sample eigenvalues is established. It has distinct features that the asymptotic mean relies on not only the population spikes but also the nonspikes and that the asymptotic variance in general depends on the population eigenvectors. In addition, the limiting Tracy-Widom law for the largest nonspiked sample eigenvalue is obtained. Estimation of the number of spikes and the convergence of the leading eigenvectors are also considered. The results hold even when the number of the spikes diverges. As a key technical tool, we develop a Central Limit Theorem for a type of random quadratic forms where the random vectors and random matrices involved are dependent. This result can be of independent interest.