Local drag of a slender rod parallel to a plane wall in a viscous fluid

The viscous drag on a slender rod by a wall is important to many biological and industrial systems. This drag critically depends on the separation between the rod and the wall and can be approximated asymptotically in specific regimes, namely far from, or very close to, the wall, but is typically determined numerically for general separations. In this note we determine an asymptotic representation of the local drag for a slender rod parallel to a wall which is valid for all separations. This is possible through matching the behaviour of a rod close to the wall and a rod far from the wall. We show that the leading order drag in both these regimes has been known since 1981 and that they can used to produce a composite representation of the drag which is valid for all separations. This is in contrast to a sphere above a wall, where no simple uniformly valid representation exists. We estimate the error on this composite representation as the separation increases, discuss how the results could be used as resistive-force theory and demonstrate their use on a two-hinged swimmer above a wall.

Simulations of particle tracking in the oligociliated mouse node and implications for left-right symmetry breaking mechanics

The concept of internal anatomical asymmetry is familiar; usually in humans the heart is on the left and the liver is on the right, however how does the developing embryo know to produce this consistent laterality? Symmetry breaking initiates with left-right asymmetric cilia-driven fluid mechanics in a small fluid-filled structure called the ventral node in mice. However the question of what converts this flow into left-right asymmetric development remains unanswered. A leading hypotheses is that flow transports morphogen containing vesicles within the node, the absorption of which results in asymmetrical gene expression. To investigate how vesicle transport might result in the situs patterns observed in wildtype and mutant experiments, we extend the open source Stokes flow package, NEAREST, to consider the hydrodynamic and Brownian motion of particles in a mouse model with flow driven by one, two, and 112 beating cilia. Three models for morphogen-containing particle released are simulated to assess their compatibility with observed results in oligociliated and wildtype mouse embryos: uniformly random release, localised cilium stress induced release, and localised release from motile cilia themselves. Only the uniformly random release model appears consistent with the data, with neither localised-release model resulting in significant transport in the oligociliated embryo.