To reveal the structures of a transition disk around a young stellar object in Lupus, Sz 91, we have performed aperture synthesis 345 GHz continuum and CO(3--2) observations with the Submillimeter Array ($sim1arcsec$--3$arcsec$ resolution), and high-
resolution imaging of polarized intensity at the $K_s$-band by using the HiCIAO instrument on the Subaru Telescope ($0farcs25$ resolution). Our observations successfully resolved the inner and outer radii of the dust disk to be 65 AU and 170 AU, respectively, which indicates that Sz 91 is a transition disk source with one of the largest known inner holes. The model fitting analysis of the spectral energy distribution reveals an H$_2$ mass of $2.4times10^{-3}$ $M_sun$ in the cold ($T<$30 K) outer part at $65<r<170$ AU by assuming a canonical gas-to-dust mass ratio of 100, although a small amount ($>3times10^{-9}$ $M_sun$) of hot ($Tsim$180 K) dust possibly remains inside the inner hole of the disk. The structure of the hot component could be interpreted as either an unresolved self-luminous companion body (not directly detected in our observations) or a narrow ring inside the inner hole. Significant CO(3--2) emission with a velocity gradient along the major axis of the dust disk is concentrated on the Sz 91 position, suggesting a rotating gas disk with a radius of 420 AU. The Sz 91 disk is possibly a rare disk in an evolutionary stage immediately after the formation of protoplanets because of the large inner hole and the lower disk mass than other transition disks studied thus far.
