Explicit expressions for arrival times of particles moving in a one-dimensional Zero-Range Process (ZRP) are computed. Particles are fed into the ZRP from an injection site and can also evaporate from anywhere in the interior of the ZRP. Two dynamics
are considered; bulk dynamics, where particle hopping and decay is proportional to the numqber of particles at each site, and surface dynamics, where only the top particle at each site can hop or evaporate. We find exact solutions in the bulk dynamics case and for a single-site ZRP obeying surface dynamics. For a multisite ZRP obeying surface dynamics, we compare simulations with approximations obtained from the steady-state limit, where mean interarrival times for both models are equivalent. Our results highlight the competition between injection and evaporation on the arrival times of particles to an absorbing site.
When a ligand that is bound to an integral membrane receptor is pulled, the membrane and the underlying cytoskeleton can deform before either the membrane delaminates from the cytoskeleton or the ligand detaches from the receptor. If the membrane del
aminates from the cytoskeleton, it may be further extruded and form a membrane tether. We develop a phenomenological model for this processes by assuming that deformations obey Hookes law up to a critical force at which the cell membrane locally detaches from the cytoskeleton and a membrane tether forms. We compute the probability of tether formation and show that they can be extruded only within an intermediate range of force loading rates and pulling velocities. The mean tether length that arises at the moment of ligand detachment is computed as are the force loading rates and pulling velocities that yield the longest tethers.
