All gravitationally bound clusters expand, due to both gas loss from their most massive members and binary heating. All are eventually disrupted tidally, either by passing molecular clouds or the gravitational potential of their host galaxies. Howeve
r, their interior evolution can follow two very different paths. Only clusters of sufficiently large initial population and size undergo the combined interior contraction and exterior expansion that leads eventually to core collapse. In all other systems, core collapse is frustrated by binary heating. These clusters globally expand for their entire lives, up to the point of tidal disruption. Using a suite of direct N-body calculations, we trace the collapse line in r_v-N space that separates these two paths. Here, r_v and N are the clusters initial virial radius and population, respectively. For realistic starting radii, the dividing N-value is from 10^4 to over 10^5. We also show that there exists a minimum population, N_min, for core collapse. Clusters with N < N_min tidally disrupt before core collapse occurs. At the Suns Galactocentric radius, R_G = 8.5 kpc, we find N_min >~ 300. The minimum population scales with Galactocentric radius as R_G^{-9/8}. The position of an observed cluster relative to the collapse line can be used to predict its future evolution. Using a small sample of open clusters, we find that most lie below the collapse line, and thus will never undergo core collapse. Most globular clusters, on the other hand, lie well above the line. In such a case, the cluster may or may not go through core collapse, depending on its initial size. We show how an accurate age determination can help settle this issue.
