When a ligand that is bound to an integral membrane receptor is pulled, the membrane and the underlying cytoskeleton can deform before either the membrane delaminates from the cytoskeleton or the ligand detaches from the receptor. If the membrane del
aminates from the cytoskeleton, it may be further extruded and form a membrane tether. We develop a phenomenological model for this processes by assuming that deformations obey Hookes law up to a critical force at which the cell membrane locally detaches from the cytoskeleton and a membrane tether forms. We compute the probability of tether formation and show that they can be extruded only within an intermediate range of force loading rates and pulling velocities. The mean tether length that arises at the moment of ligand detachment is computed as are the force loading rates and pulling velocities that yield the longest tethers.
This paper is devoted to detailed investigations of free scalar field theory on $kappa$-Minkowski space. After reviewing necessary mathematical tools we discuss in depth the Lagrangian and solutions of field equations. We analyze the spacetime symmet
ries of the model and construct the conserved charges associated with translational and Lorentz symmetry. We show that the version of the theory usually studied breaks Lorentz invariance in a subtle way: There is an additional trans-Planckian mode present, and an associated conserved charge (the number of such modes) is not a Lorentz scalar.
