The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene transfer constit
ute examples of pervasive biological phenomena that cannot be captured by tree-like representations. Starting from hundreds of genomes, we are interested in the reconstruction of potential evolutionary histories leading to the observed data. Ancestral recombination graphs represent potential histories that explicitly accommodate recombination and mutation events across orthologous genomes. However, they are computationally costly to reconstruct, usually being infeasible for more than few tens of genomes. Recently, Topological Data Analysis (TDA) methods have been proposed as robust and scalable methods that can capture the genetic scale and frequency of recombination. We build upon previous TDA developments for detecting and quantifying recombination, and present a novel framework that can be applied to hundreds of genomes and can be interpreted in terms of minimal histories of mutation and recombination events, quantifying the scales and identifying the genomic locations of recombinations. We implement this framework in a software package, called TARGet, and apply it to several examples, including small migration between different populations, human recombination, and horizontal evolution in finches inhabiting the Galapagos Islands.
We propose a new method to search for light (pseudo-)scalar particles in the spectra of compact astrophysical objects such as magnetars, pulsars, and quasars. On accounts of compact astrophysical objects having intense magnetic fields extending over
large volumes, they provide good conditions for efficient photon-particle oscillations via the Primakoff process. In particular, we show that if the coupling constant for light (<1e-2 eV) axions, g>1e-13 [1/GeV] then it is likely that absorption-like features would be detectable in the spectrum of compact astrophysical sources.
