A Deep Learning-based Quality Assessment and Segmentation System with a Large-scale Benchmark Dataset for Optical Coherence Tomographic Angiography Image

Optical Coherence Tomography Angiography (OCTA) is a non-invasive and non-contacting imaging technique providing visualization of microvasculature of retina and optic nerve head in human eyes in vivo. The adequate image quality of OCTA is the prerequisite for the subsequent quantification of retinal microvasculature. Traditionally, the image quality score based on signal strength is used for discriminating low quality. However, it is insufficient for identifying artefacts such as motion and off-centration, which rely specialized knowledge and need tedious and time-consuming manual identification. One of the most primary issues in OCTA analysis is to sort out the foveal avascular zone (FAZ) region in the retina, which highly correlates with any visual acuity disease. However, the variations in OCTA visual quality affect the performance of deep learning in any downstream marginally. Moreover, filtering the low-quality OCTA images out is both labor-intensive and time-consuming. To address these issues, we develop an automated computer-aided OCTA image processing system using deep neural networks as the classifier and segmentor to help ophthalmologists in clinical diagnosis and research. This system can be an assistive tool as it can process OCTA images of different formats to assess the quality and segment the FAZ area. The source code is freely available at https://github.com/shanzha09/COIPS.git. Another major contribution is the large-scale OCTA dataset, namely OCTA-25K-IQA-SEG we publicize for performance evaluation. It is comprised of four subsets, namely sOCTA-3$times$3-10k, sOCTA-6$times$6-14k, sOCTA-3$times$3-1.1k-seg, and dOCTA-6$times$6-1.1k-seg, which contains a total number of 25,665 images. The large-scale OCTA dataset is available at https://doi.org/10.5281/zenodo.5111975, https://doi.org/10.5281/zenodo.5111972.

Semiparametric inference on Gini indices of two semicontinuous populations under density ratio models

The Gini index is a popular inequality measure with many applications in social and economic studies. This paper studies semiparametric inference on the Gini indices of two semicontinuous populations. We characterize the distribution of each semicontinuous population by a mixture of a discrete point mass at zero and a continuous skewed positive component. A semiparametric density ratio model is then employed to link the positive components of the two distributions. We propose the maximum empirical likelihood estimators of the two Gini indices and their difference, and further investigate the asymptotic properties of the proposed estimators. The asymptotic results enable us to construct confidence intervals and perform hypothesis tests for the two Gini indices and their difference. We show that the proposed estimators are more efficient than the existing fully nonparametric estimators. The proposed estimators and the asymptotic results are also applicable to cases without excessive zero values. Simulation studies show the superiority of our proposed method over existing methods. Two real-data applications are presented using the proposed methods.

Semiparametric empirical likelihood inference with estimating equations under density ratio models

The density ratio model (DRM) provides a flexible and useful platform for combining information from multiple sources. In this paper, we consider statistical inference under two-sample DRMs with additional parameters defined through and/or additional auxiliary information expressed as estimating equations. We examine the asymptotic properties of the maximum empirical likelihood estimators (MELEs) of the unknown parameters in the DRMs and/or defined through estimating equations, and establish the chi-square limiting distributions for the empirical likelihood ratio (ELR) statistics. We show that the asymptotic variance of the MELEs of the unknown parameters does not decrease if one estimating equation is dropped. Similar properties are obtained for inferences on the cumulative distribution function and quantiles of each of the populations involved. We also propose an ELR test for the validity and usefulness of the auxiliary information. Simulation studies show that correctly specified estimating equations for the auxiliary information result in more efficient estimators and shorter confidence intervals. Two real-data examples are used for illustrations.

Semiparametric inference on general functionals of two semicontinuous populations

In this paper, we propose new semiparametric procedures for making inference on linear functionals and their functions of two semicontinuous populations. The distribution of each population is usually characterized by a mixture of a discrete point mass at zero and a continuous skewed positive component, and hence such distribution is semicontinuous in the nature. To utilize the information from both populations, we model the positive components of the two mixture distributions via a semiparametric density ratio model. Under this model setup, we construct the maximum empirical likelihood estimators of the linear functionals and their functions, and establish the asymptotic normality of the proposed estimators. We show the proposed estimators of the linear functionals are more efficient than the fully nonparametric ones. The developed asymptotic results enable us to construct confidence regions and perform hypothesis tests for the linear functionals and their functions. We further apply these results to several important summary quantities such as the moments, the mean ratio, the coefficient of variation, and the generalized entropy class of inequality measures. Simulation studies demonstrate the advantages of our proposed semiparametric method over some existing methods. Two real data examples are provided for illustration.

Semiparametric Inference of the Youden Index and the Optimal Cutoff Point under Density Ratio Models

The Youden index is a popular summary statistic for receiver operating characteristic curve. It gives the optimal cutoff point of a biomarker to distinguish the diseased and healthy individuals. In this paper, we propose to model the distributions of a biomarker for individuals in the healthy and diseased groups via a semiparametric density ratio model. Based on this model, we use the maximum empirical likelihood method to estimate the Youden index and the optimal cutoff point. We further establish the asymptotic normality of the proposed estimators and construct valid confidence intervals for the Youden index and the corresponding optimal cutoff point. The proposed method automatically covers both cases when there is no lower limit of detection (LLOD) and when there is a fixed and finite LLOD for the biomarker. Extensive simulation studies and a real data example are used to illustrate the effectiveness of the proposed method and its advantages over the existing methods.

Minor Privacy Protection Through Real-time Video Processing at the Edge

The collection of a lot of personal information about individuals, including the minor members of a family, by closed-circuit television (CCTV) cameras creates a lot of privacy concerns. Particularly, revealing childrens identifications or activities may compromise their well-being. In this paper, we investigate lightweight solutions that are affordable to edge surveillance systems, which is made feasible and accurate to identify minors such that appropriate privacy-preserving measures can be applied accordingly. State of the art deep learning architectures are modified and re-purposed in a cascaded fashion to maximize the accuracy of our model. A pipeline extracts faces from the input frames and classifies each one to be of an adult or a child. Over 20,000 labeled sample points are used for classification. We explore the timing and resources needed for such a model to be used in the Edge-Fog architecture at the edge of the network, where we can achieve near real-time performance on the CPU. Quantitative experimental results show the superiority of our proposed model with an accuracy of 92.1% in classification compared to some other face recognition based child detection approaches.

Identifying the Geometry of an Object Using Lock-In Thermography

Lock-in Thermography (LIT) is a type of Infrared Thermography (IRT) that can be used as a useful non-destructive testing (NDT) technique for the detection of subsurface anomalies in objects. Currently, LIT fails to estimate the thickness at a point on the tested object. This makes LIT unable to figure out the 3-dimensional geometry of an object. In this project, two techniques of identifying the geometry of an object using LIT are discussed. The main idea of both techniques is to find a relationship between the parameters obtained from LIT and the thickness at each data point. Technique I builds a numerical function that models the relationship between thickness, Lock-In phase, and other parameters. The function is then inverted for thickness estimation. Technique II is a quantitative method, in which a database is created with six dimensions - thickness, Lock-In phase, Lock-In amplitude and three other parameters, based on data obtained from LIT experiments or simulations. Estimated thickness is obtained by retrieving data from the database. The database can be improved based on Principal Component Analysis. Evaluation of the techniques is done by measuring root-mean-square deviation, and calculating successful rate with different tolerances. Moreover, during the application of the techniques, Stochastic Gradient Descent can be used to determine the time when sufficient data have been collected from LIT measurement to generate the estimated geometry accurately.

Trinification and the Strong P Problem

Models with spontaneously broken parity symmetry can solve the strong $CP$ problem in a natural way. We construct such a model in the context of $SU3^3$ unification. Parity has the conventional meaning in this model, and the gauge group is unified.