We present a Spitzer Infrared Spectrograph (IRS) map of H2 emission from the nearby galaxy NGC 4258 (Messier 106). The H2 emission comes from 9.4E6 Msun of warm molecular hydrogen heated to 240-1040 K in the inner anomalous arms, a signature of jet i
nteraction with the galaxy disk. The spectrum is that of a molecular hydrogen emission galaxy (MOHEG), with a large ratio of H2 over 7.7 micron PAH emission (0.37), characteristic of shocked molecular gas. We find close spatial correspondence between the H2 and CO emission from the anomalous arms. Our estimate of cold molecular gas mass based on CO emission is 10 times greater than our estimate of 1.0E8 Msun based on dust emission. We suggest that the X(CO) value is 10 times lower than the Milky Way value because of high kinetic temperature and enhanced turbulence. The H2 disk has been overrun and is being shocked by the jet cocoon, and much of the gas originally in the disk has been ejected into the galaxy halo in an X-ray-hot outflow. We measure a modest star formation rate of 0.08 Msun/yr in the central 3.4 square kpc that is consistent with the remaining gas surface density.
