Recent observations of carbon, sulphur, and titanium isotopes at redshifts z~1 and in the local stellar disc and halo have opened a new window into the study of isotopic abundance patterns and the origin of the chemical elements. Using our Galactic c
hemical evolution code GEtool, we have examined the evolution of these isotopes within the framework of a Milky Way-like system. We have three aims in this work: first, to test the claim that novae are required, in order to explain the carbon isotope patterns in the Milky Way; second, to test the claim that sulphur isotope patterns at high-redshift require an initial mass function biased towards massive stars; and third, to test extant chemical evolution models against new observations of titanium isotopes that suggest an anti-correlation between trace-to-dominant isotopes with metallicity. Based upon our dual-infall galactic chemical evolution modelling of a Milky Way-like system, and the subsequent comparison with these new and unique datasets, we conclude the following: novae are not required to understand the evolution of 12C/13C in the solar neighbourhood; a massive star-biased initial mass function is consistent with the low ratios of 12C/13C and 32S/34S seen in one high-redshift late-type spiral, but the consequent super-solar metallicity prediction for the interstellar medium in this system seems highly unlikely; and deficient isotopes of titanium are predicted to correlate positively with metallicity, in apparent disagreement with the new datasets; if confirmed, classical chemical evolution models of the Milky Way (and the associated supernovae nucleosynthetic yields) may need a substantial overhaul to be made consistent.
