The era of big data is coming, and evidence-based medicine is attracting increasing attention to improve decision making in medical practice via integrating evidence from well designed and conducted clinical research. Meta-analysis is a statistical t
echnique widely used in evidence-based medicine for analytically combining the findings from independent clinical trials to provide an overall estimation of a treatment effectiveness. The sample mean and standard deviation are two commonly used statistics in meta-analysis but some trials use the median, the minimum and maximum values, or sometimes the first and third quartiles to report the results. Thus, to pool results in a consistent format, researchers need to transform those information back to the sample mean and standard deviation. In this paper, we investigate the optimal estimation of the sample mean for meta-analysis from both theoretical and empirical perspectives. A major drawback in the literature is that the sample size, needless to say its importance, is either ignored or used in a stepwise but somewhat arbitrary manner, e.g., the famous method proposed by Hozo et al. We solve this issue by incorporating the sample size in a smoothly changing weight in the estimators to reach the optimal estimation. Our proposed estimators not only improve the existing ones significantly but also share the same virtue of the simplicity. The real data application indicates that our proposed estimators are capable to serve as rules of thumb and will be widely applied in evidence-based medicine.
Motivation: Genome-wide association studies (GWASs), which assay more than a million single nucleotide polymorphisms (SNPs) in thousands of individuals, have been widely used to identify genetic risk variants for complex diseases. However, most of th
e variants that have been identified contribute relatively small increments of risk and only explain a small portion of the genetic variation in complex diseases. This is the so-called missing heritability problem. Evidence has indicated that many complex diseases are genetically related, meaning these diseases share common genetic risk variants. Therefore, exploring the genetic correlations across multiple related studies could be a promising strategy for removing spurious associations and identifying underlying genetic risk variants, and thereby uncovering the mystery of missing heritability in complex diseases. Results: We present a general and robust method to identify genetic patterns from multiple large-scale genomic datasets. We treat the summary statistics as a matrix and demonstrate that genetic patterns will form a low-rank matrix plus a sparse component. Hence, we formulate the problem as a matrix recovering problem, where we aim to discover risk variants shared by multiple diseases/traits and those for each individual disease/trait. We propose a convex formulation for matrix recovery and an efficient algorithm to solve the problem. We demonstrate the advantages of our method using both synthesized datasets and real datasets. The experimental results show that our method can successfully reconstruct both the shared and the individual genetic patterns from summary statistics and achieve better performance compared with alternative methods under a wide range of scenarios.
In systematic reviews and meta-analysis, researchers often pool the results of the sample mean and standard deviation from a set of similar clinical trials. A number of the trials, however, reported the study using the median, the minimum and maximum
values, and/or the first and third quartiles. Hence, in order to combine results, one may have to estimate the sample mean and standard deviation for such trials. In this paper, we propose to improve the existing literature in several directions. First, we show that the sample standard deviation estimation in Hozo et al. (2005) has some serious limitations and is always less satisfactory in practice. Inspired by this, we propose a new estimation method by incorporating the sample size. Second, we systematically study the sample mean and standard deviation estimation problem under more general settings where the first and third quartiles are also available for the trials. Through simulation studies, we demonstrate that the proposed methods greatly improve the existing methods and enrich the literature. We conclude our work with a summary table that serves as a comprehensive guidance for performing meta-analysis in different situations.
Latent Dirichlet allocation (LDA) is an important hierarchical Bayesian model for probabilistic topic modeling, which attracts worldwide interests and touches on many important applications in text mining, computer vision and computational biology. T
his paper represents LDA as a factor graph within the Markov random field (MRF) framework, which enables the classic loopy belief propagation (BP) algorithm for approximate inference and parameter estimation. Although two commonly-used approximate inference methods, such as variational Bayes (VB) and collapsed Gibbs sampling (GS), have gained great successes in learning LDA, the proposed BP is competitive in both speed and accuracy as validated by encouraging experimental results on four large-scale document data sets. Furthermore, the BP algorithm has the potential to become a generic learning scheme for variants of LDA-based topic models. To this end, we show how to learn two typical variants of LDA-based topic models, such as author-topic models (ATM) and relational topic models (RTM), using BP based on the factor graph representation.
Complex network theory aims to model and analyze complex systems that consist of multiple and interdependent components. Among all studies on complex networks, topological structure analysis is of the most fundamental importance, as it represents a n
atural route to understand the dynamics, as well as to synthesize or optimize the functions, of networks. A broad spectrum of network structural patterns have been respectively reported in the past decade, such as communities, multipartites, hubs, authorities, outliers, bow ties, and others. Here, we show that most individual real-world networks demonstrate multiplex structures. That is, a multitude of known or even unknown (hidden) patterns can simultaneously situate in the same network, and moreover they may be overlapped and nested with each other to collaboratively form a heterogeneous, nested or hierarchical organization, in which different connective phenomena can be observed at different granular levels. In addition, we show that the multiplex structures hidden in exploratory networks can be well defined as well as effectively recognized within an unified framework consisting of a set of proposed concepts, models, and algorithms. Our findings provide a strong evidence that most real-world complex systems are driven by a combination of heterogeneous mechanisms that may collaboratively shape their ubiquitous multiplex structures as we observe currently. This work also contributes a mathematical tool for analyzing different sources of networks from a new perspective of unveiling multiplex structures, which will be beneficial to multiple disciplines including sociology, economics and computer science.
