We discuss moderate resolution spectra, multicolor photometry, and light curves of thirty-one of the most luminous stars and variables in the giant spiral M101. The majority are intermediate A to F-type supergiants. We present new photometry and ligh
t curves for three known irregular blue variables V2, V4 and V9) and identify a new candidate. Their spectra and variability confirm that they are LBV candidates and V9 may be in an LBV-like maximum light state or eruption.
