We solve the longstanding problem to define a functional characterization of the spectrum of the transfer matrix associated to the most general spin-1/2 representations of the 6-vertex reflection algebra for general inhomogeneous chains. The correspo
nding homogeneous limit reproduces the spectrum of the Hamiltonian of the spin-1/2 open XXZ and XXX quantum chains with the most general integrable boundaries. The spectrum is characterized by a second order finite difference functional equation of Baxter type with an inhomogeneous term which vanishes only for some special but yet interesting non-diagonal boundary conditions. This functional equation is shown to be equivalent to the known separation of variable (SOV) representation hence proving that it defines a complete characterization of the transfer matrix spectrum. The polynomial character of the Q-function allows us then to show that a finite system of equations of generalized Bethe type can be similarly used to describe the complete transfer matrix spectrum.
