Understanding the coordination of cell division timing is one of the outstanding questions in the field of developmental biology. One active control parameter of the cell cycle duration is temperature, as it can accelerate or decelerate the rate of b
iochemical reactions. However, controlled experiments at the cellular-scale are challenging due to the limited availability of biocompatible temperature sensors as well as the lack of practical methods to systematically control local temperatures and cellular dynamics. Here, we demonstrate a method to probe and control the cell division timing in Caenorhabditis elegans embryos using a combination of local laser heating and nanoscale thermometry. Local infrared laser illumination produces a temperature gradient across the embryo, which is precisely measured by in-vivo nanoscale thermometry using quantum defects in nanodiamonds. These techniques enable selective, controlled acceleration of the cell divisions, even enabling an inversion of division order at the two cell stage. Our data suggest that the cell cycle timing asynchrony of the early embryonic development in C. elegans is determined independently by individual cells rather than via cell-to-cell communication. Our method can be used to control the development of multicellular organisms and to provide insights into the regulation of cell division timings as a consequence of local perturbations.
Quantum metrology makes use of coherent superpositions to detect weak signals. While in principle the sensitivity can be improved by increasing the density of sensing particles, in practice this improvement is severely hindered by interactions betwee
n them. Using a dense ensemble of interacting electronic spins in diamond, we demonstrate a novel approach to quantum metrology. It is based on a new method of robust quantum control, which allows us to simultaneously eliminate the undesired effects associated with spin-spin interactions, disorder and control imperfections, enabling a five-fold enhancement in coherence time compared to conventional control sequences. Combined with optimal initialization and readout protocols, this allows us to break the limit for AC magnetic field sensing imposed by interactions, opening a promising avenue for the development of solid-state ensemble magnetometers with unprecedented sensitivity.
We introduce a new approach for the robust control of quantum dynamics of strongly interacting many-body systems. Our approach involves the design of periodic global control pulse sequences to engineer desired target Hamiltonians that are robust agai
nst disorder, unwanted interactions and pulse imperfections. It utilizes a matrix representation of the Hamiltonian engineering protocol based on time-domain transformations of the Pauli spin operator along the quantization axis. This representation allows us to derive a concise set of algebraic conditions on the sequence matrix to engineer robust target Hamiltonians, enabling the simple yet systematic design of pulse sequences. We show that this approach provides an efficient framework to (i) treat any secular many-body Hamiltonian and engineer it into a desired form, (ii) target dominant disorder and interaction characteristics of a given system, (iii) achieve robustness against imperfections, (iv) provide optimal sequence length within given constraints, and (v) substantially accelerate numerical searches of pulse sequences. Using this systematic approach, we develop novel sets of pulse sequences for the protection of quantum coherence, optimal quantum sensing and quantum simulation. Finally, we experimentally demonstrate the robust operation of these sequences in a system with the most general interaction form.
The hallmark of symmetry-protected topological (SPT) phases is the existence of anomalous boundary states, which can only be realized with the corresponding bulk system. In this work, we show that for every Hermitian anomalous boundary mode of the te
n Altland-Zirnbauer classes, a non-Hermitian counterpart can be constructed, whose long time dynamics provides a realization of the anomalous boundary state. We prove that the non-Hermitian counterpart is characterized by a point-gap topological invariant, and furthermore, that the invariant exactly matches that of the corresponding Hermitian anomalous boundary mode. We thus establish a correspondence between the topological classifications of $(d+1)$-dimensional gapped Hermitian systems and $d$-dimensional point-gapped non-Hermitian systems. We illustrate this general result with a number of examples in different dimensions. This work provides a new perspective on point-gap topological invariants in non-Hermitian systems.
Classifications of symmetry-protected topological (SPT) phases provide a framework to systematically understand the physical properties and potential applications of topological systems. While such classifications have been widely explored in the con
text of Hermitian systems, a complete understanding of the roles of more general non-Hermitian symmetries and their associated classification is still lacking. Here, we derive a periodic table for non-interacting SPTs with general non-Hermitian symmetries. Our analysis reveals novel non-Hermitian topological classes, while also naturally incorporating the entire classification of Hermitian systems as a special case of our scheme. Building on top of these results, we derive two independent generalizations of Kramers theorem to the non-Hermitian setting, which constrain the spectra of the system and lead to new topological invariants. To elucidate the physics behind the periodic table, we provide explicit examples of novel non-Hermitian topological invariants, focusing on the symmetry classes in zero, one and two dimensions with new topological classifications (e.g. $mathbb{Z}$ in 0D, $mathbb{Z}_2$ in 1D, 2D). These results thus provide a framework for the design and engineering of non-Hermitian symmetry-protected topological systems.
Exceptional points in non-Hermitian systems have recently been shown to possess nontrivial topological properties, and to give rise to many exotic physical phenomena. However, most studies thus far have focused on isolated exceptional points or one-d
imensional lines of exceptional points. Here, we substantially expand the space of exceptional systems by designing two-dimensional surfaces of exceptional points, and find that symmetries are a key element to protect such exceptional surfaces. We construct them using symmetry-preserving non-Hermitian deformations of topological nodal lines, and analyze the associated symmetry, topology, and physical consequences. As a potential realization, we simulate a parity-time-symmetric 3D photonic crystal and indeed find the emergence of exceptional surfaces. Our work paves the way for future explorations of systems of exceptional points in higher dimensions.
We investigate thermalization dynamics of a driven dipolar many-body quantum system through the stability of discrete time crystalline order. Using periodic driving of electronic spin impurities in diamond, we realize different types of interactions
between spins and demonstrate experimentally that the interplay of disorder, driving and interactions leads to several qualitatively distinct regimes of thermalization. For short driving periods, the observed dynamics are well described by an effective Hamiltonian which sensitively depends on interaction details. For long driving periods, the system becomes susceptible to energy exchange with the driving field and eventually enters a universal thermalizing regime, where the dynamics can be described by interaction-induced dephasing of individual spins. Our analysis reveals important differences between thermalization of long-range Ising and other dipolar spin models.
The ideas of topology have found tremendous success in Hermitian physical systems, but even richer properties exist in the more general non-Hermitian framework. Here, we theoretically propose and experimentally demonstrate a new topologically-protect
ed bulk Fermi arc which---unlike the well-known surface Fermi arcs arising from Weyl points in Hermitian systems---develops from non-Hermitian radiative losses in photonic crystal slabs. Moreover, we discover half-integer topological charges in the polarization of far-field radiation around the Fermi arc. We show that both phenomena are direct consequences of the non-Hermitian topological properties of exceptional points, where resonances coincide in their frequencies and linewidths. Our work connects the fields of topological photonics, non-Hermitian physics and singular optics, and paves the way for future exploration of non-Hermitian topological systems.
