An Apparatus for the Simulation of Breathing Disorders: Physically Meaningful Generation of Surrogate Data

Whilst debilitating breathing disorders, such as chronic obstructive pulmonary disease (COPD), are rapidly increasing in prevalence, we witness a continued integration of artificial intelligence into healthcare. While this promises improved detection and monitoring of breathing disorders, AI techniques are data hungry which highlights the importance of generating physically meaningful surrogate data. Such domain knowledge aware surrogates would enable both an improved understanding of respiratory waveform changes with different breathing disorders and different severities, and enhance the training of machine learning algorithms. To this end, we introduce an apparatus comprising of PVC tubes and 3D printed parts as a simple yet effective method of simulating both obstructive and restrictive respiratory waveforms in healthy subjects. Independent control over both inspiratory and expiratory resistances allows for the simulation of obstructive breathing disorders through the whole spectrum of FEV1/FVC spirometry ratios (used to classify COPD), ranging from healthy values to values seen in severe chronic obstructive pulmonary disease. Moreover, waveform characteristics of breathing disorders, such as a change in inspiratory duty cycle or peak flow are also observed in the waveforms resulting from use of the artificial breathing disorder simulation apparatus. Overall, the proposed apparatus provides us with a simple, effective and physically meaningful way to generate surrogate breathing disorder waveforms, a prerequisite for the use of artificial intelligence in respiratory health.

In-Ear SpO2 for Classification of Cognitive Workload

Classification of cognitive workload promises immense benefit in diverse areas ranging from driver safety to augmenting human capability through closed loop brain computer interface. The brain is the most metabolically active organ in the body and increases its metabolic activity and thus oxygen consumption with increasing cognitive demand. In this study, we explore the feasibility of in-ear SpO2 cognitive workload tracking. To this end, we preform cognitive workload assessment in 8 subjects, based on an N-back task, whereby the subjects are asked to count and remember the number of odd numbers displayed on a screen in 5 second windows. The 2 and 3-back tasks lead to either the lowest median absolute SpO2 or largest median decrease in SpO2 in all of the subjects, indicating a robust and measurable decrease in blood oxygen in response to increased cognitive workload. Using features derived from in-ear pulse oximetry, including SpO2, pulse rate and respiration rate, we were able to classify the 4 N-back task categories, over 5 second epochs, with a mean accuracy of 94.2%. Moreover, out of 21 total features, the 9 most important features for classification accuracy were all SpO2 related features. The findings suggest that in-ear SpO2 measurements provide valuable information for classification of cognitive workload over short time windows, which together with the small form factor promises a new avenue for real time cognitive workload tracking.