Learning the structure of a causal graphical model using both observational and interventional data is a fundamental problem in many scientific fields. A promising direction is continuous optimization for score-based methods, which efficiently learn
the causal graph in a data-driven manner. However, to date, those methods require constrained optimization to enforce acyclicity or lack convergence guarantees. In this paper, we present ENCO, an efficient structure learning method for directed, acyclic causal graphs leveraging observational and interventional data. ENCO formulates the graph search as an optimization of independent edge likelihoods, with the edge orientation being modeled as a separate parameter. Consequently, we can provide convergence guarantees of ENCO under mild conditions without constraining the score function with respect to acyclicity. In experiments, we show that ENCO can efficiently recover graphs with hundreds of nodes, an order of magnitude larger than what was previously possible, while handling deterministic variables and latent confounders.
We propose a Deep learning-based weak label learning method for analysing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumorcells not requiring pixel-level or tile-level annotations using Self-supervised pre-training and heterogen
eity-aware deep Multiple Instance LEarning (DeepSMILE). We apply DeepSMILE to the task of Homologous recombination deficiency (HRD) and microsatellite instability (MSI) prediction. We utilize contrastive self-supervised learning to pre-train a feature extractor on histopathology tiles of cancer tissue. Additionally, we use variability-aware deep multiple instance learning to learn the tile feature aggregation function while modeling tumor heterogeneity. Compared to state-of-the-art genomic label classification methods, DeepSMILE improves classification performance for HRD from $70.43pm4.10%$ to $83.79pm1.25%$ AUC and MSI from $78.56pm6.24%$ to $90.32pm3.58%$ AUC in a multi-center breast and colorectal cancer dataset, respectively. These improvements suggest we can improve genomic label classification performance without collecting larger datasets. In the future, this may reduce the need for expensive genome sequencing techniques, provide personalized therapy recommendations based on widely available WSIs of cancer tissue, and improve patient care with quicker treatment decisions - also in medical centers without access to genome sequencing resources.
The goal of this paper is guided image filtering, which emphasizes the importance of structure transfer during filtering by means of an additional guidance image. Where classical guided filters transfer structures using hand-designed functions, recen
t guided filters have been considerably advanced through parametric learning of deep networks. The state-of-the-art leverages deep networks to estimate the two core coefficients of the guided filter. In this work, we posit that simultaneously estimating both coefficients is suboptimal, resulting in halo artifacts and structure inconsistencies. Inspired by unsharp masking, a classical technique for edge enhancement that requires only a single coefficient, we propose a new and simplified formulation of the guided filter. Our formulation enjoys a filtering prior from a low-pass filter and enables explicit structure transfer by estimating a single coefficient. Based on our proposed formulation, we introduce a successive guided filtering network, which provides multiple filtering results from a single network, allowing for a trade-off between accuracy and efficiency. Extensive ablations, comparisons and analysis show the effectiveness and efficiency of our formulation and network, resulting in state-of-the-art results across filtering tasks like upsampling, denoising, and cross-modality filtering. Code is available at url{https://github.com/shizenglin/Unsharp-Mask-Guided-Filtering}.
