Zero-order ultrasensitivity (ZOU) is a long known and interesting phenomenon in enzyme networks. Here, a substrate is reversibly modified by two antagonistic enzymes (a push-pull system) and the fraction in modified state undergoes a sharp switching
from near-zero to near-unity at a critical value of the ratio of the enzyme concentrations, under saturation conditions. ZOU and its extensions have been studied for several decades now, ever since the seminal paper of Goldbeter and Koshland (1981); however, a complete probabilistic treatment, important for the study of fluctuations in finite populations, is still lacking. In this paper, we study ZOU using a modular approach, akin to the total quasi-steady state approximation (tQSSA). This approach leads to a set of Fokker-Planck (drift-diffusion) equations for the probability distributions of the intermediate enzyme-bound complexes, as well as the modified/unmodified fractions of substrate molecules. We obtain explicit expressions for various average fractions and their fluctuations in the linear noise approximation (LNA). The emergence of a critical point for the switching transition is rigorously established. New analytical results are derived for the average and variance of the fractional substrate concentration in various chemical states in the near-critical regime. For the total fraction in the modified state, the variance is shown to be a maximum near the critical point and decays algebraically away from it, similar to a second-order phase transition. The new analytical results are compared with existing ones as well as detailed numerical simulations using a Gillespie algorithm.
The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using N
iobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a push-pull configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.
The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using N
iobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a push-pull configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.
Prompt gamma-ray burst (GRB) emission requires some mechanism to dissipate an ultrarelativistic jet. Internal shocks or some form of electromagnetic dissipation are candidate mechanisms. Any mechanism needs to answer basic questions, such as what is
the origin of variability, what radius does dissipation occur at, and how does efficient prompt emission occur. These mechanisms also need to be consistent with how ultrarelativistic jets form and stay baryon pure despite turbulence and electromagnetic reconnection near the compact object and despite stellar entrainment within the collapsar model. We use the latest magnetohydrodynamical models of ultrarelativistic jets to explore some of these questions in the context of electromagnetic dissipation due to the slow collisional and fast collisionless reconnection mechanisms, as often associated with Sweet-Parker and Petschek reconnection, respectively. For a highly magnetized ultrarelativistic jet and typical collapsar parameters, we find that significant electromagnetic dissipation may be avoided until it proceeds catastrophically near the jet photosphere at large radii ($rsim 10^{13}--10^{14}{rm cm}$), by which the jet obtains a high Lorentz factor ($gammasim 100--1000), has a luminosity of $L_j sim 10^{50}--10^{51}ergs$, has observer variability timescales of order 1s (ranging from 0.001-10s), achieves $gammatheta_jsim 10--20 (for opening half-angle $theta_j$) and so is able to produce jet breaks, and has comparable energy available for both prompt and afterglow emission. This reconnection switch mechanism allows for highly efficient conversion of electromagnetic energy into prompt emission and associates the observed prompt GRB pulse temporal structure with dissipation timescales of some number of reconnecting current sheets embedded in the jet.[abridged]
We try to determine the Galactic structure by comparing the observed and modeled velocities of OB-associations in the 3 kpc solar neighborhood. We made N-body simulations with a rotating stellar bar. The galactic disk in our model includes gas and st
ellar subsystems. The velocities of gas particles averaged over large time intervals ($sim 8$ bar rotation periods) are compared with the observed velocities of the OB-associations. Our models reproduce the directions of the radial and azimuthal components of the observed residual velocities in the Perseus and Sagittarius regions and in the Local system. The mean difference between the model and observed velocities is $Delta V=3.3$ km s$^{-1}$. The optimal value of the solar position angle $theta_b$ providing the best agreement between the model and observed velocities is $theta_b=45pm5^circ$, in good accordance with several recent estimates. The self-gravitating stellar subsystem forms a bar, an outer ring of subclass $R_1$, and slower spiral modes. Their combined gravitational perturbation leads to time-dependent morphology in the gas subsystem, which forms outer rings with elements of the $R_1$- and $R_2$-morphology. The success of N-body simulations in the Local System is likely due to the gravity of the stellar $R_1$-ring, which is omitted in models with analytical bars.
In this paper we present simulated observations of massive self-gravitating circumstellar discs using the Atacama Large Millimetre/sub-millimetre Array (ALMA). Using a smoothed particle hydrodynamics model of a $0.2M_{odot}$ disc orbiting a $1M_{odot
}$ protostar, with a cooling model appropriate for discs at temperatures below $sim 160$K and representative dust opacities, we have constructed maps of the expected emission at sub-mm wavelengths. We have then used the CASA ALMA simulator to generate simulated images and visibilities with various array configurations and observation frequencies, taking into account the expected thermal noise and atmospheric opacities. We find that at 345 GHz (870 $mu$m) spiral structures at a resolution of a few AU should be readily detectable in approximately face-on discs out to distances of the Taurus-Auriga star-forming complex.
