The emission-line Be star HD 215227 lies within the positional error circle of the newly identified gamma-ray source AGL J2241+4454. We present new blue spectra of the star, and we point out the morphological and variability similarities to other Be
binaries. An analysis of the available optical photometry indicates a variation with a period of 60.37 +/- 0.04 d, which may correspond to an orbital modulation of the flux from the disk surrounding the Be star. The distance to the star of 2.6 kpc and its relatively large Galactic latitude suggest that the binary was ejected from the plane by a supernova explosion that created the neutron star or black hole companion. The binary and runaway properties of HD 215227 make it an attractive candidate as the optical counterpart of AGL J2241+4454 and as a new member of the small class of gamma-ray emitting binaries.
