Sub-millimeter nuclear medical imaging with high sensitivity in positron emission tomography using beta-gamma coincidences

We present a nuclear medical imaging technique, employing triple-gamma trajectory intersections from beta^+ - gamma coincidences, able to reach sub-millimeter spatial resolution in 3 dimensions with a reduced requirement of reconstructed intersections per voxel compared to a conventional PET reconstruction analysis. This $gamma$-PET technique draws on specific beta^+ - decaying isotopes, simultaneously emitting an additional photon. Exploiting the triple coincidence between the positron annihilation and the third photon, it is possible to separate the reconstructed true events from background. In order to characterize this technique, Monte-Carlo simulations and image reconstructions have been performed. The achievable spatial resolution has been found to reach ca. 0.4 mm (FWHM) in each direction for the visualization of a 22Na point source. Only 40 intersections are sufficient for a reliable sub-millimeter image reconstruction of a point source embedded in a scattering volume of water inside a voxel volume of about 1 mm^3 (high-resolution mode). Moreover, starting with an injected activity of 400 MBq for ^76Br, the same number of only about 40 reconstructed intersections are needed in case of a larger voxel volume of 2 x 2 x 3~mm^3 (high-sensitivity mode). Requiring such a low number of reconstructed events significantly reduces the required acquisition time for image reconstruction (in the above case to about 140 s) and thus may open up the perspective for a quasi real-time imaging.

Medical Application Studies at ELI-NP

We study the production of radioisotopes for nuclear medicine in (gamma,gamma) photoexcitation reactions or (gamma,xn + yp) photonuclear reactions for the examples of ^195mPt, ^117mSn and ^44Ti with high flux [(10^13 - 10^15) gamma/s], small beam diameter and small energy band width (Delta E/E ~ 10^-3 -10^-4) gamma beams. In order to realize an optimum gamma-focal spot, a refractive gamma-lens consisting of a stack of many concave micro-lenses will be used. It allows for the production of a high specific activity and the use of enriched isotopes. For photonuclear reactions with a narrow gamma beam, the energy deposition in the target can be reduced by using a stack of thin target wires, hence avoiding direct stopping of the Compton electrons and e^+e^- pairs. The well-defined initial excitation energy of the compound nucleus leads to a small number of reaction channels and enables new combinations of target isotope and final radioisotope. The narrow-bandwidth gamma excitation may make use of collective resonances in gamma-width, leading to increased cross sections. (gamma,gamma) isomer production via specially selected gamma cascades allows to produce high specific activity in multiple excitations, where no back-pumping of the isomer to the ground state occurs. The produced isotopes will open the way for completely new clinical applications of radioisotopes. For example ^195mPt could be used to verify the patients response to chemotherapy with platinum compounds before a complete treatment is performed. In targeted radionuclide therapy the short-range Auger and conversion electrons of ^195mPt and ^117mSn enable a very local treatment. The generator ^44Ti allows for a PET with an additional gamma-quantum (gamma-PET), resulting in a reduced dose or better spatial resolution.

Nuclear photonics at ultra-high counting rates and higher multipole excitations

Next-generation gamma beams beams from laser Compton-backscattering facilities like ELI-NP (Bucharest)] or MEGa-Ray (Livermore) will drastically exceed the photon flux presently available at existing facilities, reaching or even exceeding 10^13 gamma/sec. The beam structure as presently foreseen for MEGa-Ray and ELI-NP builds upon a structure of macro-pulses (~120 Hz) for the electron beam, accelerated with X-band technology at 11.5 GHz, resulting in a micro structure of 87 ps distance between the electron pulses acting as mirrors for a counterpropagating intense laser. In total each 8.3 ms a gamma pulse series with a duration of about 100 ns will impinge on the target, resulting in an instantaneous photon flux of about 10^18 gamma/s, thus introducing major challenges in view of pile-up. Novel gamma optics will be applied to monochromatize the gamma beam to ultimately Delta E/E~10^-6. Thus level-selective spectroscopy of higher multipole excitations will become accessible with good contrast for the first time. Fast responding gamma detectors, e.g. based on advanced scintillator technology (e.g. LaBr3(Ce)) allow for measurements with count rates as high as 10^6-10^7 gamma/s without significant drop of performance. Data handling adapted to the beam conditions could be performed by fast digitizing electronics, able to sample data traces during the micro-pulse duration, while the subsequent macro-pulse gap of ca. 8 ms leaves ample time for data readout. A ball of LaBr3 detectors with digital readout appears to best suited for this novel type of nuclear photonics at ultra-high counting rates.

Nuclear Photonics

With new gamma-beam facilities like MEGa-ray at LLNL (USA) or ELI-NP at Bucharest with 10^13 g/s and a bandwidth of Delta E_g/E_g ~10^-3, a new era of g-beams with energies <=20 MeV comes into operation, compared to the present world-leading HIGS facility (Duke Univ., USA) with 10^8 g/s and Delta E_g/E_g~0.03. Even a seeded quantum FEL for g-beams may become possible, with much higher brilliance and spectral flux. At the same time new exciting possibilities open up for focused g-beams. We describe a new experiment at the g-beam of the ILL reactor (Grenoble), where we observed for the first time that the index of refraction for g-beams is determined by virtual pair creation. Using a combination of refractive and reflective optics, efficient monochromators for g-beams are being developed. Thus we have to optimize the system of the g-beam facility, the g-beam optics and g-detectors. We can trade g-intensity for band width, going down to Delta E_g/E_g ~ 10^-6 and address individual nuclear levels. Nuclear photonics stresses the importance of nuclear applications. We can address with g-beams individual nuclear isotopes and not just elements like with X-ray beams. Compared to X rays, g-beams can penetrate much deeper into big samples like radioactive waste barrels, motors or batteries. We can perform tomography and microscopy studies by focusing down to micron resolution using Nucl. Reson. Fluorescence for detection with eV resolution and high spatial resolution. We discuss the dominating M1 and E1 excitations like scissors mode, two-phonon quadrupole octupole excitations, pygmy dipole excitations or giant dipole excitations under the new facet of applications. We find many new applications in biomedicine, green energy, radioactive waste management or homeland security. Also more brilliant secondary beams of neutrons and positrons can be produced.

High-Intensity and High-Brightness Source of Moderated Positrons Using a Brilliant gamma Beam

Presently large efforts are conducted towards the development of highly brilliant gamma beams via Compton back scattering of photons from a high-brilliance electron beam, either on the basis of a normal-conducting electron linac or a (superconducting) Energy Recovery Linac (ERL). Particularly ERLs provide an extremely brilliant electron beam, thus enabling to generate highest-quality gamma beams. A 2.5 MeV gamma beam with an envisaged intensity of 10^15 s^-1, as ultimately envisaged for an ERL-based gamma-beam facility, narrow band width (10^-3), and extremely low emittance (10^-4 mm^2 mrad^2) offers the possibility to produce a high-intensity bright polarized positron beam. Pair production in a face-on irradiated W converter foil (200 micron thick, 10 mm long) would lead to the emission of 2 x 10^13 (fast) positrons per second, which is four orders of magnitude higher compared to strong radioactive ^22Na sources conventionally used in the laboratory.Using a stack of converter foils and subsequent positron moderation, a high-intensity low-energy beam of moderated positrons can be produced. Two different source setups are presented: a high-brightness positron beam with a diameter as low as 0.2 mm, and a high-intensity beam of 3 x 10^11 moderated positrons per second. Hence, profiting from an improved moderation efficiency, the envisaged positron intensity would exceed that of present high-intensity positron sources by a factor of 100.

Introducing the Fission-Fusion Reaction Process: Using a Laser-Accelerated Th Beam to produce Neutron-Rich Nuclei towards the N=126 Waiting Point of the r Process

We propose to produce neutron-rich nuclei in the range of the astrophysical r-process around the waiting point N=126 by fissioning a dense laser-accelerated thorium ion bunch in a thorium target (covered by a CH2 layer), where the light fission fragments of the beam fuse with the light fission fragments of the target. Via the hole-boring mode of laser Radiation Pressure Acceleration using a high-intensity, short pulse laser, very efficiently bunches of 232Th with solid-state density can be generated from a Th layer, placed beneath a deuterated polyethylene foil, both forming the production target. Th ions laser-accelerated to about 7 MeV/u will pass through a thin CH2 layer placed in front of a thicker second Th foil closely behind the production target and disintegrate into light and heavy fission fragments. In addition, light ions (d,C) from the CD2 production target will be accelerated as well to about 7 MeV/u, inducing the fission process of 232Th also in the second Th layer. The laser-accelerated ion bunches with solid-state density, which are about 10^14 times more dense than classically accelerated ion bunches, allow for a high probability that generated fission products can fuse again. In contrast to classical radioactive beam facilities, where intense but low-density radioactive beams are merged with stable targets, the novel fission-fusion process draws on the fusion between neutron-rich, short-lived, light fission fragments both from beam and target. The high ion beam density may lead to a strong collective modification of the stopping power in the target, leading to significant range enhancement. Using a high-intensity laser as envisaged for the ELI-Nuclear Physics project in Bucharest (ELI-NP), estimates promise a fusion yield of about 10^3 ions per laser pulse in the mass range of A=180-190, thus enabling to approach the r-process waiting point at N=126.

Collective deceleration: toward a compact beam dump

With the increasing development of laser accelerators, the electron energy is already beyond GeV and even higher in near future. Conventional beam dump based on ionization or radiation loss mechanism is cumbersome and costly, also has radiological hazards. We revisit the stopping power of high-energy charged particles in matter and discuss the associated problem of beam dump from the point of view of collective deceleration. The collective stopping length in an ionized gas can be several orders of magnitude shorter than the Bethe-Bloch and multiple electromagnetic cascades stopping length in solid. At the mean time, the tenuous density of the gas makes the radioactivation negligible. Such a compact and non-radioactivating beam dump works well for short and dense bunches, which is typically generated from laser wakefield accelerator.