We report the first observation of the decay D^+ -> eta e^+ nu_e in two analyses, which combined provide a branching fraction of B(D+ -> eta e nu) = (2.16 +/- 0.53 +/- 0.07) x 10^{-4}. We also provide an improved measurement of B(D+ -> eta e nu) = (1
1.4 +/- 0.9 +/- 0.4) x 10^{-4}, provide the first form factor measurement, and set the improved upper limit B(D+ -> phi e nu) < 0.9 x 10^{-4} (90% C.L.).
