Among various approaches toward quantum computation, measurement-based quantum computation (MBQC) multiplexed in time domain is currently a promising method for addressing the need for scalability. MBQC requires two components: cluster states and pro
grammable measurements. With time-domain multiplexing, the former has been realized on an ultra-large-scale. The latter, however, has remained unrealized, leaving the large-scale cluster states unused. In this work, we make such a measurement system and use it to demonstrate basic quantum operations multiplexed in the time domain with 25 MHz clock frequency. We verify transformations of the input states and their nonclassicalities for single-step quantum operations and also observe multi-step quantum operations up to one hundred steps.
