The two-Equation of State (EoS) model is used to describe the hadron-quark phase transition in asymmetric matter formed at high density in heavy-ion collisions. For the quark phase, the three-flavor Nambu--Jona-Lasinio (NJL) effective theory is used
to investigate the influence of dynamical quark mass effects on the phase transition. At variance to the MIT-Bag results, with fixed current quark masses, the main important effect of the chiral dynamics is the appearance of an End-Point for the coexistence zone. We show that a first order hadron-quark phase transition may take place in the region T=(50-80)MeV and rho_B=(2-4)rho_0, which is possible to be probed in the new planned facilities, such as FAIR at GSI-Darmstadt and NICA at JINR-Dubna. From isospin properties of the mixed phase somepossible signals are suggested. The importance of chiral symmetry and dynamical quark mass on the hadron-quark phase transition is stressed. The difficulty of an exact location of Critical-End-Point comes from its appearance in a region of competition between chiral symmetry breaking and confinement, where our knowledge of effective QCD theories is still rather uncertain.
