On the Origins and Control of Community Types in the Human Microbiome

Microbiome-based stratification of healthy individuals into compositional categories, referred to as community types, holds promise for drastically improving personalized medicine. Despite this potential, the existence of community types and the degree of their distinctness have been highly debated. Here we adopted a dynamic systems approach and found that heterogeneity in the interspecific interactions or the presence of strongly interacting species is sufficient to explain community types, independent of the topology of the underlying ecological network. By controlling the presence or absence of these strongly interacting species we can steer the microbial ecosystem to any desired community type. This open-loop control strategy still holds even when the community types are not distinct but appear as dense regions within a continuous gradient. This finding can be used to develop viable therapeutic strategies for shifting the microbial composition to a healthy configuration

Spatially localized attacks on interdependent networks: the existence of a finite critical attack size

Many real world complex systems such as infrastructure, communication and transportation networks are embedded in space, where entities of one system may depend on entities of other systems. These systems are subject to geographically localized failures due to malicious attacks or natural disasters. Here we study the resilience of a system composed of two interdependent spatially embedded networks to localized geographical attacks. We find that if an attack is larger than a finite (zero fraction of the system) critical size, it will spread through the entire system and lead to its complete collapse. If the attack is below the critical size, it will remain localized. In contrast, under random attack a finite fraction of the system needs to be removed to initiate system collapse. We present both numerical simulations and a theoretical approach to analyze and predict the effect of local attacks and the critical attack size. Our results demonstrate the high risk of local attacks on interdependent spatially embedded infrastructures and can be useful for designing more resilient systems.

Simultaneous first and second order percolation transitions in interdependent networks

In a system of interdependent networks, an initial failure of nodes invokes a cascade of iterative failures that may lead to a total collapse of the whole system in a form of an abrupt first order transition. When the fraction of initial failed nodes $1-p$ reaches criticality, $p=p_c$, the abrupt collapse occurs by spontaneous cascading failures. At this stage, the giant component decreases slowly in a plateau form and the number of iterations in the cascade, $tau$, diverges. The origin of this plateau and its increasing with the size of the system remained unclear. Here we find that simultaneously with the abrupt first order transition a spontaneous second order percolation occurs during the cascade of iterative failures. This sheds light on the origin of the plateau and on how its length scales with the size of the system. Understanding the critical nature of the dynamical process of cascading failures may be useful for designing strategies for preventing and mitigating catastrophic collapses.

The extreme vulnerability of interdependent spatially embedded networks

Recent studies show that in interdependent networks a very small failure in one network may lead to catastrophic consequences. Above a critical fraction of interdependent nodes, even a single node failure can invoke cascading failures that may abruptly fragment the system, while below this critical dependency (CD) a failure of few nodes leads only to small damage to the system. So far, the research has been focused on interdependent random networks without space limitations. However, many real systems, such as power grids and the Internet, are not random but are spatially embedded. Here we analytically and numerically analyze the stability of systems consisting of interdependent spatially embedded networks modeled as lattice networks. Surprisingly, we find that in lattice systems, in contrast to non-embedded systems, there is no CD and textit{any} small fraction of interdependent nodes leads to an abrupt collapse. We show that this extreme vulnerability of very weakly coupled lattices is a consequence of the critical exponent describing the percolation transition of a single lattice. Our results are important for understanding the vulnerabilities and for designing robust interdependent spatial embedded networks.