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Register a new userEstimation of Local Average Treatment Effect by Data Combination
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It is important to estimate the local average treatment effect (LATE) when compliance with a treatment assignment is incomplete. The previously proposed methods for LATE estimation required all relevant variables to be jointly observed in a single dataset; however, it is sometimes difficult or even impossible to collect such data in many real-world problems for technical or privacy reasons. We consider a novel problem setting in which LATE, as a function of covariates, is nonparametrically identified from the combination of separately observed datasets. For estimation, we show that the direct least squares method, which was originally developed for estimating the average treatment effect under complete compliance, is applicable to our setting. However, model selection and hyperparameter tuning for the direct least squares estimator can be unstable in practice since it is defined as a solution to the minimax problem. We then propose a weighted least squares estimator that enables simpler model selection by avoiding the minimax objective formulation. Unlike the inverse probability weighted (IPW) estimator, the proposed estimator directly uses the pre-estimated weight without inversion, avoiding the problems caused by the IPW methods. We demonstrate the effectiveness of our method through experiments using synthetic and real-world datasets.
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The goal of many scientific experiments including A/B testing is to estimate the average treatment effect (ATE), which is defined as the difference between the expected outcomes of two or more treatments. In this paper, we consider a situation where an experimenter can assign a treatment to research subjects sequentially. In adaptive experimental design, the experimenter is allowed to change the probability of assigning a treatment using past observations for estimating the ATE efficiently. However, with this approach, it is difficult to apply a standard statistical method to construct an estimator because the observations are not independent and identically distributed. We thus propose an algorithm for efficient experiments with estimators constructed from dependent samples. We also introduce a sequential testing framework using the proposed estimator. To justify our proposed approach, we provide finite and infinite sample analyses. Finally, we experimentally show that the proposed algorithm exhibits preferable performance.
We investigate how to exploit structural similarities of an individuals potential outcomes (POs) under different treatments to obtain better estimates of conditional average treatment effects in finite samples. Especially when it is unknown whether a treatment has an effect at all, it is natural to hypothesize that the POs are similar - yet, some existing strategies for treatment effect estimation employ regularization schemes that implicitly encourage heterogeneity even when it does not exist and fail to fully make use of shared structure. In this paper, we investigate and compare three end-to-end learning strategies to overcome this problem - based on regularization, reparametrization and a flexible multi-task architecture - each encoding inductive bias favoring shared behavior across POs. To build understanding of their relative strengths, we implement all strategies using neural networks and conduct a wide range of semi-synthetic experiments. We observe that all three approaches can lead to substantial improvements upon numerous baselines and gain insight into performance differences across various experimental settings.
Federated learning is an appealing framework for analyzing sensitive data from distributed health data networks. Under this framework, data partners at local sites collaboratively build an analytical model under the orchestration of a coordinating site, while keeping the data decentralized. While integrating information from multiple sources may boost statistical efficiency, existing federated learning methods mainly assume data across sites are homogeneous samples of the global population, failing to properly account for the extra variability across sites in estimation and inference. Drawing on a multi-hospital electronic health records network, we develop an efficient and interpretable tree-based ensemble of personalized treatment effect estimators to join results across hospital sites, while actively modeling for the heterogeneity in data sources through site partitioning. The efficiency of this approach is demonstrated by a study of causal effects of oxygen saturation on hospital mortality and backed up by comprehensive numerical results.
The research described herewith is to re-visit the classical doubly robust estimation of average treatment effect by conducting a systematic study on the comparisons, in the sense of asymptotic efficiency, among all possible combinations of the estimated propensity score and outcome regression. To this end, we consider all nine combinations under, respectively, parametric, nonparametric and semiparametric structures. The comparisons provide useful information on when and how to efficiently utilize the model structures in practice. Further, when there is model-misspecification, either propensity score or outcome regression, we also give the corresponding comparisons. Three phenomena are observed. Firstly, when all models are correctly specified, any combination can achieve the same semiparametric efficiency bound, which coincides with the existing results of some combinations. Secondly, when the propensity score is correctly modeled and estimated, but the outcome regression is misspecified parametrically or semiparametrically, the asymptotic variance is always larger than or equal to the semiparametric efficiency bound. Thirdly, in contrast, when the propensity score is misspecified parametrically or semiparametrically, while the outcome regression is correctly modeled and estimated, the asymptotic variance is not necessarily larger than the semiparametric efficiency bound. In some cases, the super-efficiency phenomenon occurs. We also conduct a small numerical study.
Bayesian approaches have become increasingly popular in causal inference problems due to their conceptual simplicity, excellent performance and in-built uncertainty quantification (posterior credible sets). We investigate Bayesian inference for average treatment effects from observational data, which is a challenging problem due to the missing counterfactuals and selection bias. Working in the standard potential outcomes framework, we propose a data-driven modification to an arbitrary (nonparametric) prior based on the propensity score that corrects for the first-order posterior bias, thereby improving performance. We illustrate our method for Gaussian process (GP) priors using (semi-)synthetic data. Our experiments demonstrate significant improvement in both estimation accuracy and uncertainty quantification compared to the unmodified GP, rendering our approach highly competitive with the state-of-the-art.
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