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Feedback patterns in simulating intestinal wall motions: interdisciplinary approach to the motility mechanisms

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 Added by Garri Davydyan
 Publication date 2021
  fields Biology
and research's language is English




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Ability of smooth muscles to contract in response to distension plays a crucial role in motor function of intestine. Qualitative analysis of dynamical models using myogenic active property of smooth muscles has shown well agreement with physiologic data. Considered as a self-regulatory unit, function of gastrointestinal (GI) segment is assumed to be regulated by integration of basis patterns providing accumulation and propagation of intestinal content. By implementing external, depending on neural system, variable to the previous model, and considering two attaches to one another reservoirs as a physical analogue of the segmental partition of intestine, a system of six ODE equations, three for each reservoir, describes coordinated wall motions and propagation of the content from one reservoir to another. It was shown that besides negative feedback (NFB), other functional patterns, namely positive feedback (PFB) and reciprocal links (RL) are involved in regulations of filling-emptying cycle. Being integrated in a whole functional system these three patterns expressed in a matrix form represent basis elements of imaginary part of coquaternion which with identity basis component is an algebraically closed structure under addition and multiplication of its elements. A coquaternion ring may be considered as a model of inner self-regulatory functional structure providing coordinated wall motions of GI tract portions.



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Coordination in circular and longitudinal muscle motions are of crucial importance in the motor function of gastrointestinal (GI) tract. Intestinal wall motions depend on myogenic-active properties of smooth muscles layers of intestinal wall, which is the ability to create active contractile forces in response to distension. Considering the stress in the circular and longitudinal smooth muscles as a sum of passive, depending on muscle deformations, and active, depending on muscle tone, components, and also assuming that the change in the muscle tone depends on the current stress-strain condition, the system of four ordinary differential equations (ODE) is obtained, which describes filling-emptying cycle of intestinal segment as a process of coordinated activities of circular and longitudinal muscles of intestinal wall. A general approach in formulating the modelling conditions is based on the previously described model restricted to the circularly distensible reservoir of constant length. Obtained results illustrate the character of coordinated activities of two orthogonal muscle layers, which are alternating phases of reciprocally and uniformly changing modalities such as stretching of the wall and muscle tone. The results also contribute to the existing understanding of the roles of Auerbachs and Meisners intermuscular and submucous neural plexuses in regulations of autonomous intestinal motility, as well as clarify functional mechanisms of the interstitial cells of Cajal (ICC) in triggering of smooth muscle contractions.
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