Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userAn Explainable AI System for the Diagnosis of High Dimensional Biomedical Data
95
0
0.0
(
0
)
Added by
Michael Thrun PhD
Publication date
2021
fields
Informatics Engineering
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
Typical state of the art flow cytometry data samples consists of measures of more than 100.000 cells in 10 or more features. AI systems are able to diagnose such data with almost the same accuracy as human experts. However, there is one central challenge in such systems: their decisions have far-reaching consequences for the health and life of people, and therefore, the decisions of AI systems need to be understandable and justifiable by humans. In this work, we present a novel explainable AI method, called ALPODS, which is able to classify (diagnose) cases based on clusters, i.e., subpopulations, in the high-dimensional data. ALPODS is able to explain its decisions in a form that is understandable for human experts. For the identified subpopulations, fuzzy reasoning rules expressed in the typical language of domain experts are generated. A visualization method based on these rules allows human experts to understand the reasoning used by the AI system. A comparison to a selection of state of the art explainable AI systems shows that ALPODS operates efficiently on known benchmark data and also on everyday routine case data.
rate research
Read More
The aim of this project is to develop and test advanced analytical methods to improve the prediction accuracy of Credit Risk Models, preserving at the same time the model interpretability. In particular, the project focuses on applying an explainable machine learning model to bank-related databases. The input data were obtained from open data. Over the total proven models, CatBoost has shown the highest performance. The algorithm implementation produces a GINI of 0.68 after tuning the hyper-parameters. SHAP package is used to provide a global and local interpretation of the model predictions to formulate a human-comprehensive approach to understanding the decision-maker algorithm. The 20 most important features are selected using the Shapley values to present a full human-understandable model that reveals how the attributes of an individual are related to its model prediction.
Cybersecurity is a domain where the data distribution is constantly changing with attackers exploring newer patterns to attack cyber infrastructure. Intrusion detection system is one of the important layers in cyber safety in todays world. Machine learning based network intrusion detection systems started showing effective results in recent years. With deep learning models, detection rates of network intrusion detection system are improved. More accurate the model, more the complexity and hence less the interpretability. Deep neural networks are complex and hard to interpret which makes difficult to use them in production as reasons behind their decisions are unknown. In this paper, we have used deep neural network for network intrusion detection and also proposed explainable AI framework to add transparency at every stage of machine learning pipeline. This is done by leveraging Explainable AI algorithms which focus on making ML models less of black boxes by providing explanations as to why a prediction is made. Explanations give us measurable factors as to what features influence the prediction of a cyberattack and to what degree. These explanations are generated from SHAP, LIME, Contrastive Explanations Method, ProtoDash and Boolean Decision Rules via Column Generation. We apply these approaches to NSL KDD dataset for intrusion detection system and demonstrate results.
We investigate molecular mechanisms of resistant or sensitive response of cancer drug combination therapies in an inductive and interpretable manner. Though deep learning algorithms are widely used in the drug synergy prediction problem, it is still an open problem to formulate the prediction model with biological meaning to investigate the mysterious mechanisms of synergy (MoS) for the human-AI collaboration in healthcare systems. To address the challenges, we propose a deep graph neural network, IDSP (Interpretable Deep Signaling Pathways), to incorporate the gene-gene as well as gene-drug regulatory relationships in synergic drug combination predictions. IDSP automatically learns weights of edges based on the gene and drug node relations, i.e., signaling interactions, by a multi-layer perceptron (MLP) and aggregates information in an inductive manner. The proposed architecture generates interpretable drug synergy prediction by detecting important signaling interactions, and can be implemented when the underlying molecular mechanism encounters unseen genes or signaling pathways. We test IDWSP on signaling networks formulated by genes from 46 core cancer signaling pathways and drug combinations from NCI ALMANAC drug combination screening data. The experimental results demonstrated that 1) IDSP can learn from the underlying molecular mechanism to make prediction without additional drug chemical information while achieving highly comparable performance with current state-of-art methods; 2) IDSP show superior generality and flexibility to implement the synergy prediction task on both transductive tasks and inductive tasks. 3) IDSP can generate interpretable results by detecting different salient signaling patterns (i.e. MoS) for different cell lines.
Artificial Intelligence (AI) has made leapfrogs in development across all the industrial sectors especially when deep learning has been introduced. Deep learning helps to learn the behaviour of an entity through methods of recognising and interpreting patterns. Despite its limitless potential, the mystery is how deep learning algorithms make a decision in the first place. Explainable AI (XAI) is the key to unlocking AI and the black-box for deep learning. XAI is an AI model that is programmed to explain its goals, logic, and decision making so that the end users can understand. The end users can be domain experts, regulatory agencies, managers and executive board members, data scientists, users that use AI, with or without awareness, or someone who is affected by the decisions of an AI model. Chest CT has emerged as a valuable tool for the clinical diagnostic and treatment management of the lung diseases associated with COVID-19. AI can support rapid evaluation of CT scans to differentiate COVID-19 findings from other lung diseases. However, how these AI tools or deep learning algorithms reach such a decision and which are the most influential features derived from these neural networks with typically deep layers are not clear. The aim of this study is to propose and develop XAI strategies for COVID-19 classification models with an investigation of comparison. The results demonstrate promising quantification and qualitative visualisations that can further enhance the clinicians understanding and decision making with more granular information from the results given by the learned XAI models.
Explainability of AI systems is critical for users to take informed actions and hold systems accountable. While opening the opaque box is important, understanding who opens the box can govern if the Human-AI interaction is effective. In this paper, we conduct a mixed-methods study of how two different groups of whos--people with and without a background in AI--perceive different types of AI explanations. These groups were chosen to look at how disparities in AI backgrounds can exacerbate the creator-consumer gap. We quantitatively share what the perceptions are along five dimensions: confidence, intelligence, understandability, second chance, and friendliness. Qualitatively, we highlight how the AI background influences each groups interpretations and elucidate why the differences might exist through the lenses of appropriation and cognitive heuristics. We find that (1) both groups had unwarranted faith in numbers, to different extents and for different reasons, (2) each group found explanatory values in different explanations that went beyond the usage we designed them for, and (3) each group had different requirements of what counts as humanlike explanations. Using our findings, we discuss potential negative consequences such as harmful manipulation of user trust and propose design interventions to mitigate them. By bringing conscious awareness to how and why AI backgrounds shape perceptions of potential creators and consumers in XAI, our work takes a formative step in advancing a pluralistic Human-centered Explainable AI discourse.
suggested questions
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
