Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userInheritance-guided Hierarchical Assignment for Clinical Automatic Diagnosis
166
0
0.0
(
0
)
Added by
Yichao Du
Publication date
2021
fields
Informatics Engineering
and research's language is
English
Ask ChatGPT about the research
No Arabic abstract
Clinical diagnosis, which aims to assign diagnosis codes for a patient based on the clinical note, plays an essential role in clinical decision-making. Considering that manual diagnosis could be error-prone and time-consuming, many intelligent approaches based on clinical text mining have been proposed to perform automatic diagnosis. However, these methods may not achieve satisfactory results due to the following challenges. First, most of the diagnosis codes are rare, and the distribution is extremely unbalanced. Second, existing methods are challenging to capture the correlation between diagnosis codes. Third, the lengthy clinical note leads to the excessive dispersion of key information related to codes. To tackle these challenges, we propose a novel framework to combine the inheritance-guided hierarchical assignment and co-occurrence graph propagation for clinical automatic diagnosis. Specifically, we propose a hierarchical joint prediction strategy to address the challenge of unbalanced codes distribution. Then, we utilize graph convolutional neural networks to obtain the correlation and semantic representations of medical ontology. Furthermore, we introduce multi attention mechanisms to extract crucial information. Finally, extensive experiments on MIMIC-III dataset clearly validate the effectiveness of our method.
rate research
Read More
Spoken dialog systems have seen applications in many domains, including medical for automatic conversational diagnosis. State-of-the-art dialog managers are usually driven by deep reinforcement learning models, such as deep Q networks (DQNs), which learn by interacting with a simulator to explore the entire action space since real conversations are limited. However, the DQN-based automatic diagnosis models do not achieve satisfying performances when adapted to new, unseen diseases with only a few training samples. In this work, we propose the Prototypical Q Networks (ProtoQN) as the dialog manager for the automatic diagnosis systems. The model calculates prototype embeddings with real conversations between doctors and patients, learning from them and simulator-augmented dialogs more efficiently. We create both supervised and few-shot learning tasks with the Muzhi corpus. Experiments showed that the ProtoQN significantly outperformed the baseline DQN model in both supervised and few-shot learning scenarios, and achieves state-of-the-art few-shot learning performances.
Recent explorations of large-scale pre-trained language models (PLMs) such as GPT-3 have revealed the power of PLMs with huge amounts of parameters, setting off a wave of training ever-larger PLMs. However, training a large-scale PLM requires tremendous amounts of computational resources, which is time-consuming and expensive. In addition, existing large-scale PLMs are mainly trained from scratch individually, ignoring the availability of many existing well-trained PLMs. To this end, we explore the question that how can previously trained PLMs benefit training larger PLMs in future. Specifically, we introduce a novel pre-training framework named knowledge inheritance (KI), which combines both self-learning and teacher-guided learning to efficiently train larger PLMs. Sufficient experimental results demonstrate the feasibility of our KI framework. We also conduct empirical analyses to explore the effects of teacher PLMs pre-training settings, including model architecture, pre-training data, etc. Finally, we show that KI can well support lifelong learning and knowledge transfer.
Taxonomies are of great value to many knowledge-rich applications. As the manual taxonomy curation costs enormous human effects, automatic taxonomy construction is in great demand. However, most existing automatic taxonomy construction methods can only build hypernymy taxonomies wherein each edge is limited to expressing the is-a relation. Such a restriction limits their applicability to more diverse real-world tasks where the parent-child may carry different relations. In this paper, we aim to construct a task-guided taxonomy from a domain-specific corpus and allow users to input a seed taxonomy, serving as the task guidance. We propose an expansion-based taxonomy construction framework, namely HiExpan, which automatically generates key term list from the corpus and iteratively grows the seed taxonomy. Specifically, HiExpan views all children under each taxonomy node forming a coherent set and builds the taxonomy by recursively expanding all these sets. Furthermore, HiExpan incorporates a weakly-supervised relation extraction module to extract the initial children of a newly-expanded node and adjusts the taxonomy tree by optimizing its global structure. Our experiments on three real datasets from different domains demonstrate the effectiveness of HiExpan for building task-guided taxonomies.
Medical code assignment, which predicts medical codes from clinical texts, is a fundamental task of intelligent medical information systems. The emergence of deep models in natural language processing has boosted the development of automatic assignment methods. However, recent advanced neural architectures with flat convolutions or multi-channel feature concatenation ignore the sequential causal constraint within a text sequence and may not learn meaningful clinical text representations, especially for lengthy clinical notes with long-term sequential dependency. This paper proposes a Dilated Convolutional Attention Network (DCAN), integrating dilated convolutions, residual connections, and label attention, for medical code assignment. It adopts dilated convolutions to capture complex medical patterns with a receptive field which increases exponentially with dilation size. Experiments on a real-world clinical dataset empirically show that our model improves the state of the art.
We focus on exploring various approaches of Zero-Shot Learning (ZSL) and their explainability for a challenging yet important supervised learning task notorious for training data scarcity, i.e. Depression Symptoms Detection (DSD) from text. We start with a comprehensive synthesis of different components of our ZSL modeling and analysis of our ground truth samples and Depression symptom clues curation process with the help of a practicing clinician. We next analyze the accuracy of various state-of-the-art ZSL models and their potential enhancements for our task. Further, we sketch a framework for the use of ZSL for hierarchical text-based explanation mechanism, which we call, Syntax Tree-Guided Semantic Explanation (STEP). Finally, we summarize experiments from which we conclude that we can use ZSL models and achieve reasonable accuracy and explainability, measured by a proposed Explainability Index (EI). This work is, to our knowledge, the first work to exhaustively explore the efficacy of ZSL models for DSD task, both in terms of accuracy and explainability.
suggested questions
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
