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Register a new userCharacterizing and Detecting Freezing of Gait using Multi-modal Physiological Signals
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Freezing-of-gait a mysterious symptom of Parkinsons disease and defined as a sudden loss of ability to move forward. Common treatments of freezing episodes are currently of moderate efficacy and can likely be improved through a reliable freezing evaluation. Basic-science studies about the characterization of freezing episodes and a 24/7 evidence-support freezing detection system can contribute to the reliability of the evaluation in daily life. In this study, we analyzed multi-modal features from brain, eye, heart, motion, and gait activity from 15 participants with idiopathic Parkinsons disease and 551 freezing episodes induced by turning in place. Statistical analysis was first applied on 248 of the 551 to determine which multi-modal features were associated with freezing episodes. Features significantly associated with freezing episodes were ranked and used for the freezing detection. We found that eye-stabilization speed during turning and lower-body trembling measure significantly associated with freezing episodes and used for freezing detection. Using a leave-one-subject-out cross-validation, we obtained a sensitivity of 97%+/-3%, a specificity of 96%+/-7%, a precision of 73%+/-21%, a Matthews correlation coefficient of 0.82+/-0.15, and an area under the Precision-Recall curve of 0.94+/-0.05. According to the Precision-Recall curves, the proposed freezing detection method using the multi-modal features performed better than using single-modal features.
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Physiological signals, such as the electrocardiogram and the phonocardiogram are very often corrupted by noisy sources. Usually, artificial intelligent algorithms analyze the signal regardless of its quality. On the other hand, physicians use a completely orthogonal strategy. They do not assess the entire recording, instead they search for a segment where the fundamental and abnormal waves are easily detected, and only then a prognostic is attempted. Inspired by this fact, a new algorithm that automatically selects an optimal segment for a post-processing stage, according to a criteria defined by the user is proposed. In the process, a Neural Network is used to compute the output state probability distribution for each sample. Using the aforementioned quantities, a graph is designed, whereas state transition constraints are physically imposed into the graph and a set of constraints are used to retrieve a subset of the recording that maximizes the likelihood function, proposed by the user. The developed framework is tested and validated in two applications. In both cases, the system performance is boosted significantly, e.g in heart sound segmentation, sensitivity increases 2.4% when compared to the standard approaches in the literature.
The fast-growing techniques of measuring and fusing multi-modal biomedical signals enable advanced motor intent decoding schemes of lowerlimb exoskeletons, meeting the increasing demand for rehabilitative or assistive applications of take-home healthcare. Challenges of exoskeletons motor intent decoding schemes remain in making a continuous prediction to compensate for the hysteretic response caused by mechanical transmission. In this paper, we solve this problem by proposing an ahead of time continuous prediction of lower limb kinematics, with the prediction of knee angles during level walking as a case study. Firstly, an end-to-end kinematics prediction network(KinPreNet), consisting of a feature extractor and an angle predictor, is proposed and experimentally compared with features and methods traditionally used in ahead-of-time prediction of gait phases. Secondly, inspired by the electromechanical delay(EMD), we further explore our algorithms capability of compensating response delay of mechanical transmission by validating the performance of the different sections of prediction time. And we experimentally reveal the time boundary of compensating the hysteretic response. Thirdly, a comparison of employing EMG signals or not is performed to reveal the EMG and kinematic signals collaborated contributions to the continuous prediction. During the experiments, EMG signals of nine muscles and knee angles calculated from inertial measurement unit (IMU) signals are recorded from ten healthy subjects. To the best of our knowledge, this is the first study of continuously predicting lower-limb kinematics in an ahead-of-time manner based on the electromechanical delay (EMD).
Underneath the ear skin there are richly branching vascular and neural networks that ultimately connecting to our heart and brain. Hence, the three-dimensional (3D) mapping of auricular electrophysiological signals could provide a new perspective for biomedical studies such as diagnosis of cardiovascular diseases and neurological disorders. However, it is still extremely challenging for current sensing techniques to cover the entire ultra-curved auricle. Here, we report a graphene-based ear-conformable sensing device with embedded and distributed 3D electrodes which enable full-auricle physiological monitoring. The sensing device, which incorporates programable 3D electrode thread array and personalized auricular mold, has 3D-conformable sensing interfaces with curved auricular skin, and was developed using one-step multi-material 3D-printing process. As a proof-of-concept, spatiotemporal auricular electrical skin resistance (AESR) mapping was demonstrated. For the first time, 3D AESR contours were generated and human subject-specific AESR distributions among a population were observed. From the data of 17 volunteers, the auricular region-specific AESR changes after cycling exercise were observed in 98% of the tests and were validated via machine learning techniques. Correlations of AESR with heart rate and blood pressure were also studied using statistical analysis. This 3D electronic platform and AESR-based new biometrical findings show promising biomedical applications.
Brain-computer interface (BCI) systems have potential as assistive technologies for individuals with severe motor impairments. Nevertheless, individuals must first participate in many training sessions to obtain adequate data for optimizing the classification algorithm and subsequently acquiring brain-based control. Such traditional training paradigms have been dubbed unengaging and unmotivating for users. In recent years, it has been shown that the synergy of virtual reality (VR) and a BCI can lead to increased user engagement. This study created a 3-class BCI with a rather elaborate EEG signal processing pipeline that heavily utilizes machine learning. The BCI initially presented sham feedback but was eventually driven by EEG associated with motor imagery. The BCI tasks consisted of motor imagery of the feet and left and right hands, which were used to navigate a single-path maze in VR. Ten of the eleven recruited participants achieved online performance superior to chance (p < 0.01), while the majority successfully completed more than 70% of the prescribed navigational tasks. These results indicate that the proposed paradigm warrants further consideration as neurofeedback BCI training tool. A paradigm that allows users, from their perspective, control from the outset without the need for prior data collection sessions.
Flow-like experiences at work are important for productivity and worker well-being. However, it is difficult to objectively detect when workers are experiencing flow in their work. In this paper, we investigate how to predict a workers focus state based on physiological signals. We conducted a lab study to collect physiological data from knowledge workers experienced different levels of flow while performing work tasks. We used the nine characteristics of flow to design tasks that would induce different focus states. A manipulation check using the Flow Short Scale verified that participants experienced three distinct flow states, one overly challenging non-flow state, and two types of flow states, balanced flow, and automatic flow. We built machine learning classifiers that can distinguish between non-flow and flow states with 0.889 average AUC and rest states from working states with 0.98 average AUC. The results show that physiological sensing can detect focused flow states of knowledge workers and can enable ways to for individuals and organizations to improve both productivity and worker satisfaction.
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