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Register a new userSegmentation and Optimal Region Selection of Physiological Signals using Deep Neural Networks and Combinatorial Optimization
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Physiological signals, such as the electrocardiogram and the phonocardiogram are very often corrupted by noisy sources. Usually, artificial intelligent algorithms analyze the signal regardless of its quality. On the other hand, physicians use a completely orthogonal strategy. They do not assess the entire recording, instead they search for a segment where the fundamental and abnormal waves are easily detected, and only then a prognostic is attempted. Inspired by this fact, a new algorithm that automatically selects an optimal segment for a post-processing stage, according to a criteria defined by the user is proposed. In the process, a Neural Network is used to compute the output state probability distribution for each sample. Using the aforementioned quantities, a graph is designed, whereas state transition constraints are physically imposed into the graph and a set of constraints are used to retrieve a subset of the recording that maximizes the likelihood function, proposed by the user. The developed framework is tested and validated in two applications. In both cases, the system performance is boosted significantly, e.g in heart sound segmentation, sensitivity increases 2.4% when compared to the standard approaches in the literature.
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Freezing-of-gait a mysterious symptom of Parkinsons disease and defined as a sudden loss of ability to move forward. Common treatments of freezing episodes are currently of moderate efficacy and can likely be improved through a reliable freezing evaluation. Basic-science studies about the characterization of freezing episodes and a 24/7 evidence-support freezing detection system can contribute to the reliability of the evaluation in daily life. In this study, we analyzed multi-modal features from brain, eye, heart, motion, and gait activity from 15 participants with idiopathic Parkinsons disease and 551 freezing episodes induced by turning in place. Statistical analysis was first applied on 248 of the 551 to determine which multi-modal features were associated with freezing episodes. Features significantly associated with freezing episodes were ranked and used for the freezing detection. We found that eye-stabilization speed during turning and lower-body trembling measure significantly associated with freezing episodes and used for freezing detection. Using a leave-one-subject-out cross-validation, we obtained a sensitivity of 97%+/-3%, a specificity of 96%+/-7%, a precision of 73%+/-21%, a Matthews correlation coefficient of 0.82+/-0.15, and an area under the Precision-Recall curve of 0.94+/-0.05. According to the Precision-Recall curves, the proposed freezing detection method using the multi-modal features performed better than using single-modal features.
We study the problem of optimal power allocation in a single-hop ad hoc wireless network. In solving this problem, we propose a hybrid neural architecture inspired by the algorithmic unfolding of the iterative weighted minimum mean squared error (WMMSE) method, that we denote as unfolded WMMSE (UWMMSE). The learnable weights within UWMMSE are parameterized using graph neural networks (GNNs), where the time-varying underlying graphs are given by the fading interference coefficients in the wireless network. These GNNs are trained through a gradient descent approach based on multiple instances of the power allocation problem. Once trained, UWMMSE achieves performance comparable to that of WMMSE while significantly reducing the computational complexity. This phenomenon is illustrated through numerical experiments along with the robustness and generalization to wireless networks of different densities and sizes.
Magnetic resonance imaging (MRI) has been proposed as a complimentary method to measure bone quality and assess fracture risk. However, manual segmentation of MR images of bone is time-consuming, limiting the use of MRI measurements in the clinical practice. The purpose of this paper is to present an automatic proximal femur segmentation method that is based on deep convolutional neural networks (CNNs). This study had institutional review board approval and written informed consent was obtained from all subjects. A dataset of volumetric structural MR images of the proximal femur from 86 subject were manually-segmented by an expert. We performed experiments by training two different CNN architectures with multiple number of initial feature maps and layers, and tested their segmentation performance against the gold standard of manual segmentations using four-fold cross-validation. Automatic segmentation of the proximal femur achieved a high dice similarity score of 0.94$pm$0.05 with precision = 0.95$pm$0.02, and recall = 0.94$pm$0.08 using a CNN architecture based on 3D convolution exceeding the performance of 2D CNNs. The high segmentation accuracy provided by CNNs has the potential to help bring the use of structural MRI measurements of bone quality into clinical practice for management of osteoporosis.
Combinatorial optimization problems are typically tackled by the branch-and-bound paradigm. We propose a new graph convolutional neural network model for learning branch-and-bound variable selection policies, which leverages the natural variable-constraint bipartite graph representation of mixed-integer linear programs. We train our model via imitation learning from the strong branching expert rule, and demonstrate on a series of hard problems that our approach produces policies that improve upon state-of-the-art machine-learning methods for branching and generalize to instances significantly larger than seen during training. Moreover, we improve for the first time over expert-designed branching rules implemented in a state-of-the-art solver on large problems. Code for reproducing all the experiments can be found at https://github.com/ds4dm/learn2branch.
Cardiovascular diseases are one of the most severe causes of mortality, taking a heavy toll of lives annually throughout the world. The continuous monitoring of blood pressure seems to be the most viable option, but this demands an invasive process, bringing about several layers of complexities. This motivates us to develop a method to predict the continuous arterial blood pressure (ABP) waveform through a non-invasive approach using photoplethysmogram (PPG) signals. In addition we explore the advantage of deep learning as it would free us from sticking to ideally shaped PPG signals only, by making handcrafted feature computation irrelevant, which is a shortcoming of the existing approaches. Thus, we present, PPG2ABP, a deep learning based method, that manages to predict the continuous ABP waveform from the input PPG signal, with a mean absolute error of 4.604 mmHg, preserving the shape, magnitude and phase in unison. However, the more astounding success of PPG2ABP turns out to be that the computed values of DBP, MAP and SBP from the predicted ABP waveform outperforms the existing works under several metrics, despite that PPG2ABP is not explicitly trained to do so.
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