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Register a new userPairwise Relation Learning for Semi-supervised Gland Segmentation
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Yutong Xie
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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Accurate and automated gland segmentation on histology tissue images is an essential but challenging task in the computer-aided diagnosis of adenocarcinoma. Despite their prevalence, deep learning models always require a myriad number of densely annotated training images, which are difficult to obtain due to extensive labor and associated expert costs related to histology image annotations. In this paper, we propose the pairwise relation-based semi-supervised (PRS^2) model for gland segmentation on histology images. This model consists of a segmentation network (S-Net) and a pairwise relation network (PR-Net). The S-Net is trained on labeled data for segmentation, and PR-Net is trained on both labeled and unlabeled data in an unsupervised way to enhance its image representation ability via exploiting the semantic consistency between each pair of images in the feature space. Since both networks share their encoders, the image representation ability learned by PR-Net can be transferred to S-Net to improve its segmentation performance. We also design the object-level Dice loss to address the issues caused by touching glands and combine it with other two loss functions for S-Net. We evaluated our model against five recent methods on the GlaS dataset and three recent methods on the CRAG dataset. Our results not only demonstrate the effectiveness of the proposed PR-Net and object-level Dice loss, but also indicate that our PRS^2 model achieves the state-of-the-art gland segmentation performance on both benchmarks.
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Automated segmentation in medical image analysis is a challenging task that requires a large amount of manually labeled data. However, manually annotating medical data is often laborious, and most existing learning-based approaches fail to accurately delineate object boundaries without effective geometric constraints. Contrastive learning, a sub-area of self-supervised learning, has recently been noted as a promising direction in multiple application fields. In this work, we present a novel Contrastive Voxel-wise Representation Learning (CVRL) method with geometric constraints to learn global-local visual representations for volumetric medical image segmentation with limited annotations. Our framework can effectively learn global and local features by capturing 3D spatial context and rich anatomical information. Specifically, we introduce a voxel-to-volume contrastive algorithm to learn global information from 3D images, and propose to perform local voxel-to-voxel contrast to explicitly make use of local cues in the embedding space. Moreover, we integrate an elastic interaction-based active contour model as a geometric regularization term to enable fast and reliable object delineations in an end-to-end learning manner. Results on the Atrial Segmentation Challenge dataset demonstrate superiority of our proposed scheme, especially in a setting with a very limited number of annotated data.
Segmentation is a prerequisite yet challenging task for medical image analysis. In this paper, we introduce a novel deeply supervised active learning approach for finger bones segmentation. The proposed architecture is fine-tuned in an iterative and incremental learning manner. In each step, the deep supervision mechanism guides the learning process of hidden layers and selects samples to be labeled. Extensive experiments demonstrated that our method achieves competitive segmentation results using less labeled samples as compared with full annotation.
We investigate the generalization of semi-supervised learning (SSL) to diverse pixel-wise tasks. Although SSL methods have achieved impressive results in image classification, the performances of applying them to pixel-wise tasks are unsatisfactory due to their need for dense outputs. In addition, existing pixel-wise SSL approaches are only suitable for certain tasks as they usually require to use task-specific properties. In this paper, we present a new SSL framework, named Guided Collaborative Training (GCT), for pixel-wise tasks, with two main technical contributions. First, GCT addresses the issues caused by the dense outputs through a novel flaw detector. Second, the modules in GCT learn from unlabeled data collaboratively through two newly proposed constraints that are independent of task-specific properties. As a result, GCT can be applied to a wide range of pixel-wise tasks without structural adaptation. Our extensive experiments on four challenging vision tasks, including semantic segmentation, real image denoising, portrait image matting, and night image enhancement, show that GCT outperforms state-of-the-art SSL methods by a large margin. Our code available at: https://github.com/ZHKKKe/PixelSSL.
Ultrasound (US) is a non-invasive yet effective medical diagnostic imaging technique for the COVID-19 global pandemic. However, due to complex feature behaviors and expensive annotations of US images, it is difficult to apply Artificial Intelligence (AI) assisting approaches for lungs multi-symptom (multi-label) classification. To overcome these difficulties, we propose a novel semi-supervised Two-Stream Active Learning (TSAL) method to model complicated features and reduce labeling costs in an iterative procedure. The core component of TSAL is the multi-label learning mechanism, in which label correlations information is used to design multi-label margin (MLM) strategy and confidence validation for automatically selecting informative samples and confident labels. On this basis, a multi-symptom multi-label (MSML) classification network is proposed to learn discriminative features of lung symptoms, and a human-machine interaction is exploited to confirm the final annotations that are used to fine-tune MSML with progressively labeled data. Moreover, a novel lung US dataset named COVID19-LUSMS is built, currently containing 71 clinical patients with 6,836 images sampled from 678 videos. Experimental evaluations show that TSAL using only 20% data can achieve superior performance to the baseline and the state-of-the-art. Qualitatively, visualization of both attention map and sample distribution confirms the good consistency with the clinic knowledge.
Recent semi-supervised learning (SSL) methods are commonly based on pseudo labeling. Since the SSL performance is greatly influenced by the quality of pseudo labels, mutual learning has been proposed to effectively suppress the noises in the pseudo supervision. In this work, we propose robust mutual learning that improves the prior approach in two aspects. First, the vanilla mutual learners suffer from the coupling issue that models may converge to learn homogeneous knowledge. We resolve this issue by introducing mean teachers to generate mutual supervisions so that there is no direct interaction between the two students. We also show that strong data augmentations, model noises and heterogeneous network architectures are essential to alleviate the model coupling. Second, we notice that mutual learning fails to leverage the networks own ability for pseudo label refinement. Therefore, we introduce self-rectification that leverages the internal knowledge and explicitly rectifies the pseudo labels before the mutual teaching. Such self-rectification and mutual teaching collaboratively improve the pseudo label accuracy throughout the learning. The proposed robust mutual learning demonstrates state-of-the-art performance on semantic segmentation in low-data regime.
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