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Register a new userVision-based Estimation of MDS-UPDRS Gait Scores for Assessing Parkinsons Disease Motor Severity
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Added by
Mandy Lu
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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Parkinsons disease (PD) is a progressive neurological disorder primarily affecting motor function resulting in tremor at rest, rigidity, bradykinesia, and postural instability. The physical severity of PD impairments can be quantified through the Movement Disorder Society Unified Parkinsons Disease Rating Scale (MDS-UPDRS), a widely used clinical rating scale. Accurate and quantitative assessment of disease progression is critical to developing a treatment that slows or stops further advancement of the disease. Prior work has mainly focused on dopamine transport neuroimaging for diagnosis or costly and intrusive wearables evaluating motor impairments. For the first time, we propose a computer vision-based model that observes non-intrusive video recordings of individuals, extracts their 3D body skeletons, tracks them through time, and classifies the movements according to the MDS-UPDRS gait scores. Experimental results show that our proposed method performs significantly better than chance and competing methods with an F1-score of 0.83 and a balanced accuracy of 81%. This is the first benchmark for classifying PD patients based on MDS-UPDRS gait severity and could be an objective biomarker for disease severity. Our work demonstrates how computer-assisted technologies can be used to non-intrusively monitor patients and their motor impairments. The code is available at https://github.com/mlu355/PD-Motor-Severity-Estimation.
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Parkinsons disease (PD) is the second most common neurodegenerative disease worldwide and affects around 1% of the (60+ years old) elderly population in industrial nations. More than 80% of PD patients suffer from motor symptoms, which could be well addressed if a personalized medication schedule and dosage could be administered to them. However, such personalized medication schedule requires a continuous, objective and precise measurement of motor symptoms experienced by the patients during their regular daily activities. In this work, we propose the use of a wrist-worn smart-watch, which is equipped with 3D motion sensors, for estimating the motor fluctuation severity of PD patients in a free-living environment. We introduce a novel network architecture, a post-training scheme and a custom loss function that accounts for label noise to improve the results of our previous work in this domain and to establish a novel benchmark for nine-level PD motor state estimation.
One major challenge in the medication of Parkinsons disease is that the severity of the disease, reflected in the patients motor state, cannot be measured using accessible biomarkers. Therefore, we develop and examine a variety of statistical models to detect the motor state of such patients based on sensor data from a wearable device. We find that deep learning models consistently outperform a classical machine learning model applied on hand-crafted features in this time series classification task. Furthermore, our results suggest that treating this problem as a regression instead of an ordinal regression or a classification task is most appropriate. For consistent model evaluation and training, we adopt the leave-one-subject-out validation scheme to the training of deep learning models. We also employ a class-weighting scheme to successfully mitigate the problem of high multi-class imbalances in this domain. In addition, we propose a customized performance measure that reflects the requirements of the involved medical staff on the model. To solve the problem of limited availability of high quality training data, we propose a transfer learning technique which helps to improve model performance substantially. Our results suggest that deep learning techniques offer a high potential to autonomously detect motor states of patients with Parkinsons disease.
As the senior population rapidly increases, it is challenging yet crucial to provide effective long-term care for seniors who live at home or in senior care facilities. Smart senior homes, which have gained widespread interest in the healthcare community, have been proposed to improve the well-being of seniors living independently. In particular, non-intrusive, cost-effective sensors placed in these senior homes enable gait characterization, which can provide clinically relevant information including mobility level and early neurodegenerative disease risk. In this paper, we present a method to perform gait analysis from a single camera placed within the home. We show that we can accurately calculate various gait parameters, demonstrating the potential for our system to monitor the long-term gait of seniors and thus aid clinicians in understanding a patients medical profile.
The study reports the performance of Parkinsons disease (PD) patients to operate Motor-Imagery based Brain-Computer Interface (MI-BCI) and compares three selected pre-processing and classification approaches. The experiment was conducted on 7 PD patients who performed a total of 14 MI-BCI sessions targeting lower extremities. EEG was recorded during the initial calibration phase of each session, and the specific BCI models were produced by using Spectrally weighted Common Spatial Patterns (SpecCSP), Source Power Comodulation (SPoC) and Filter-Bank Common Spatial Patterns (FBCSP) methods. The results showed that FBCSP outperformed SPoC in terms of accuracy, and both SPoC and SpecCSP in terms of the false-positive ratio. The study also demonstrates that PD patients were capable of operating MI-BCI, although with lower accuracy.
Computer vision researchers prefer to estimate age from face images because facial features provide useful information. However, estimating age from face images becomes challenging when people are distant from the camera or occluded. A persons gait is a unique biometric feature that can be perceived efficiently even at a distance. Thus, gait can be used to predict age when face images are not available. However, existing gait-based classification or regression methods ignore the ordinal relationship of different ages, which is an important clue for age estimation. This paper proposes an ordinal distribution regression with a global and local convolutional neural network for gait-based age estimation. Specifically, we decompose gait-based age regression into a series of binary classifications to incorporate the ordinal age information. Then, an ordinal distribution loss is proposed to consider the inner relationships among these classifications by penalizing the distribution discrepancy between the estimated value and the ground truth. In addition, our neural network comprises a global and three local sub-networks, and thus, is capable of learning the global structure and local details from the head, body, and feet. Experimental results indicate that the proposed approach outperforms state-of-the-art gait-based age estimation methods on the OULP-Age dataset.
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