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Register a new userAudiovisual Speech-In-Noise (SIN) Performance of Young Adults with ADHD
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Gavindya Jayawardena
Publication date
2020
fields
Biology
and research's language is
English
Authors
Gavindya Jayawardena
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Adolescents with Attention-deficit/hyperactivity disorder (ADHD) have difficulty processing speech with background noise due to reduced inhibitory control and working memory capacity (WMC). This paper presents a pilot study of an audiovisual Speech-In-Noise (SIN) task for young adults with ADHD compared to age-matched controls using eye-tracking measures. The audiovisual SIN task consists of varying six levels of background babble, accompanied by visual cues. A significant difference between ADHD and neurotypical (NT) groups was observed at 15 dB signal-to-noise ratio (SNR). These results contribute to the literature of young adults with ADHD.
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Attention-deficit/hyperactivity disorder (ADHD) is increasingly being diagnosed in adults, but the neural mechanisms underlying its distinct clinical symptoms (hyperactivity and inattention) remain poorly understood. Here, we used a nested-spectral partition approach to study resting-state brain networks for ADHD patients and healthy adults and adopted hierarchical segregation and integration to predict clinical symptoms. Adult ADHD is typically characterized by an overintegrated interaction within default mode network. Limbic system is dominantly affected by ADHD and has an earlier aging functional pattern, but salient attention system is preferably affected by age and shows an opposite aging trajectory. More importantly, these two systems selectively and robustly predict distinct ADHD symptoms. Earlier-aging limbic system prefers to predict hyperactivity, and age-affected salient attention system better predicts inattention. Our findings provide a more comprehensive and deeper understanding of the neural basis of distinct ADHD symptoms and could contribute to the development of more objective clinical diagnoses.
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Recently Segev et al. (Phys. Rev. E 64,2001, Phys.Rev.Let. 88, 2002) made long-term observations of spontaneous activity of in-vitro cortical networks, which differ from predictions of current models in many features. In this paper we generalize the EI cortical model introduced in a previous paper (S.Scarpetta et al. Neural Comput. 14, 2002), including intrinsic white noise and analyzing effects of noise on the spontaneous activity of the nonlinear system, in order to account for the experimental results of Segev et al.. Analytically we can distinguish different regimes of activity, depending from the model parameters. Using analytical results as a guide line, we perform simulations of the nonlinear stochastic model in two different regimes, B and C. The Power Spectrum Density (PSD) of the activity and the Inter-Event-Interval (IEI) distributions are computed, and compared with experimental results. In regime B the network shows stochastic resonance phenomena and noise induces aperiodic collective synchronous oscillations that mimic experimental observations at 0.5 mM Ca concentration. In regime C the model shows spontaneous synchronous periodic activity that mimic activity observed at 1 mM Ca concentration and the PSD shows two peaks at the 1st and 2nd harmonics in agreement with experiments at 1 mM Ca. Moreover (due to intrinsic noise and nonlinear activation function effects) the PSD shows a broad band peak at low frequency. This feature, observed experimentally, does not find explanation in the previous models. Besides we identify parametric changes (namely increase of noise or decreasing of excitatory connections) that reproduces the fading of periodicity found experimentally at long times, and we identify a way to discriminate between those two possible effects measuring experimentally the low frequency PSD.
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We present a modular framework for articulatory animation synthesis using speech motion capture data obtained with electromagnetic articulography (EMA). Adapting a skeletal animation approach, the articulatory motion data is applied to a three-dimensional (3D) model of the vocal tract, creating a portable resource that can be integrated in an audiovisual (AV) speech synthesis platform to provide realistic animation of the tongue and teeth for a virtual character. The framework also provides an interface to articulatory animation synthesis, as well as an example application to illustrate its use with a 3D game engine. We rely on cross-platform, open-source software and open standards to provide a lightweight, accessible, and portable workflow.
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