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Register a new userA New Estimation Algorithm for Box-Cox Transformation Cure Rate Model and Comparison With EM Algorithm
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Souvik Roy
Publication date
2019
fields
Mathematical Statistics
and research's language is
English
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In this paper, we develop a new estimation procedure based on the non-linear conjugate gradient (NCG) algorithm for the Box-Cox transformation cure rate model. We compare the performance of the NCG algorithm with the well-known expectation maximization (EM) algorithm through a simulation study and show the advantages of the NCG algorithm over the EM algorithm. In particular, we show that the NCG algorithm allows simultaneous maximization of all model parameters when the likelihood surface is flat with respect to a Box-Cox model parameter. This is a big advantage over the EM algorithm, where a profile likelihood approach has been proposed in the literature that may not provide satisfactory results. We finally use the NCG algorithm to analyze a well-known melanoma data and show that it results in a better fit.
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Estimation of the precision matrix (or inverse covariance matrix) is of great importance in statistical data analysis. However, as the number of parameters scales quadratically with the dimension p, computation becomes very challenging when p is large. In this paper, we propose an adaptive sieving reduction algorithm to generate a solution path for the estimation of precision matrices under the $ell_1$ penalized D-trace loss, with each subproblem being solved by a second-order algorithm. In each iteration of our algorithm, we are able to greatly reduce the number of variables in the problem based on the Karush-Kuhn-Tucker (KKT) conditions and the sparse structure of the estimated precision matrix in the previous iteration. As a result, our algorithm is capable of handling datasets with very high dimensions that may go beyond the capacity of the existing methods. Moreover, for the sub-problem in each iteration, other than solving the primal problem directly, we develop a semismooth Newton augmented Lagrangian algorithm with global linear convergence on the dual problem to improve the efficiency. Theoretical properties of our proposed algorithm have been established. In particular, we show that the convergence rate of our algorithm is asymptotically superlinear. The high efficiency and promising performance of our algorithm are illustrated via extensive simulation studies and real data applications, with comparison to several state-of-the-art solvers.
In this paper, we propose a new estimation methodology based on a projected non-linear conjugate gradient (PNCG) algorithm with an efficient line search technique. We develop a general PNCG algorithm for a survival model incorporating a proportion cure under a competing risks setup, where the initial number of competing risks are exposed to elimination after an initial treatment (known as destruction). In the literature, expectation maximization (EM) algorithm has been widely used for such a model to estimate the model parameters. Through an extensive Monte Carlo simulation study, we compare the performance of our proposed PNCG with that of the EM algorithm and show the advantages of our proposed method. Through simulation, we also show the advantages of our proposed methodology over other optimization algorithms (including other conjugate gradient type methods) readily available as R software packages. To show these we assume the initial number of competing risks to follow a negative binomial distribution although our general algorithm allows one to work with any competing risks distribution. Finally, we apply our proposed algorithm to analyze a well-known melanoma data.
In Statistics, log-concave density estimation is a central problem within the field of nonparametric inference under shape constraints. Despite great progress in recent years on the statistical theory of the canonical estimator, namely the log-concave maximum likelihood estimator, adoption of this method has been hampered by the complexities of the non-smooth convex optimization problem that underpins its computation. We provide enhanced understanding of the structural properties of this optimization problem, which motivates the proposal of new algorithms, based on both randomized and Nesterov smoothing, combined with an appropriate integral discretization of increasing accuracy. We prove that these methods enjoy, both with high probability and in expectation, a convergence rate of order $1/T$ up to logarithmic factors on the objective function scale, where $T$ denotes the number of iterations. The benefits of our new computational framework are demonstrated on both synthetic and real data, and our implementation is available in a github repository texttt{LogConcComp} (Log-Concave Computation).
Handling missing values plays an important role in the analysis of survival data, especially, the ones marked by cure fraction. In this paper, we discuss the properties and implementation of stochastic approximations to the expectation-maximization (EM) algorithm to obtain maximum likelihood (ML) type estimates in situations where missing data arise naturally due to right censoring and a proportion of individuals are immune to the event of interest. A flexible family of three parameter exponentiated-Weibull (EW) distributions is assumed to characterize lifetimes of the non-immune individuals as it accommodates both monotone (increasing and decreasing) and non-monotone (unimodal and bathtub) hazard functions. To evaluate the performance of the SEM algorithm, an extensive simulation study is carried out under various parameter settings. Using likelihood ratio test we also carry out model discrimination within the EW family of distributions. Furthermore, we study the robustness of the SEM algorithm with respect to outliers and algorithm starting values. Few scenarios where stochastic EM (SEM) algorithm outperforms the well-studied EM algorithm are also examined in the given context. For further demonstration, a real survival data on cutaneous melanoma is analyzed using the proposed cure rate model with EW lifetime distribution and the proposed estimation technique. Through this data, we illustrate the applicability of the likelihood ratio test towards rejecting several well-known lifetime distributions that are nested within the wider class of EW distributions.
In this contribution, we propose a generic online (also sometimes called adaptive or recursive) version of the Expectation-Maximisation (EM) algorithm applicable to latent variable models of independent observations. Compared to the algorithm of Titterington (1984), this approach is more directly connected to the usual EM algorithm and does not rely on integration with respect to the complete data distribution. The resulting algorithm is usually simpler and is shown to achieve convergence to the stationary points of the Kullback-Leibler divergence between the marginal distribution of the observation and the model distribution at the optimal rate, i.e., that of the maximum likelihood estimator. In addition, the proposed approach is also suitable for conditional (or regression) models, as illustrated in the case of the mixture of linear regressions model.
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