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Register a new userNonparametric graphical model for counts
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Added by
Arkaprava Roy
Publication date
2019
fields
Mathematical Statistics
and research's language is
English
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Although multivariate count data are routinely collected in many application areas, there is surprisingly little work developing flexible models for characterizing their dependence structure. This is particularly true when interest focuses on inferring the conditional independence graph. In this article, we propose a new class of pairwise Markov random field-type models for the joint distribution of a multivariate count vector. By employing a novel type of transformation, we avoid restricting to non-negative dependence structures or inducing other restrictions through truncations. Taking a Bayesian approach to inference, we choose a Dirichlet process prior for the distribution of a random effect to induce great flexibility in the specification. An efficient Markov chain Monte Carlo (MCMC) algorithm is developed for posterior computation. We prove various theoretical properties, including posterior consistency, and show that our COunt Nonparametric Graphical Analysis (CONGA) approach has good performance relative to competitors in simulation studies. The methods are motivated by an application to neuron spike count data in mice.
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We introduce the Multiple Quantile Graphical Model (MQGM), which extends the neighborhood selection approach of Meinshausen and Buhlmann for learning sparse graphical models. The latter is defined by the basic subproblem of modeling the conditional mean of one variable as a sparse function of all others. Our approach models a set of conditional quantiles of one variable as a sparse function of all others, and hence offers a much richer, more expressive class of conditional distribution estimates. We establish that, under suitable regularity conditions, the MQGM identifies the exact conditional independencies with probability tending to one as the problem size grows, even outside of the usual homoskedastic Gaussian data model. We develop an efficient algorithm for fitting the MQGM using the alternating direction method of multipliers. We also describe a strategy for sampling from the joint distribution that underlies the MQGM estimate. Lastly, we present detailed experiments that demonstrate the flexibility and effectiveness of the MQGM in modeling hetereoskedastic non-Gaussian data.
A framework is presented to model instances and degrees of local item dependence within the context of diagnostic classification models (DCMs). The study considers an undirected graphical model to describe dependent structure of test items and draws inference based on pseudo-likelihood. The new modeling framework explicitly addresses item interactions beyond those explained by latent classes and thus is more flexible and robust against the violation of local independence. It also facilitates concise interpretation of item relations by regulating complexity of a network underlying the test items. The viability and effectiveness are demonstrated via simulation and a real data example. Results from the simulation study suggest that the proposed methods adequately recover the model parameters in the presence of locally dependent items and lead to a substantial improvement in estimation accuracy compared to the standard DCM approach. The analysis of real data demonstrates that the graphical DCM provides a useful summary of item interactions in regards to the existence and extent of local dependence.
We consider modeling, inference, and computation for analyzing multivariate binary data. We propose a new model that consists of a low dimensional latent variable component and a sparse graphical component. Our study is motivated by analysis of item response data in cognitive assessment and has applications to many disciplines where item response data are collected. Standard approaches to item response data in cognitive assessment adopt the multidimensional item response theory (IRT) models. However, human cognition is typically a complicated process and thus may not be adequately described by just a few factors. Consequently, a low-dimensional latent factor model, such as the multidimensional IRT models, is often insufficient to capture the structure of the data. The proposed model adds a sparse graphical component that captures the remaining ad hoc dependence. It reduces to a multidimensional IRT model when the graphical component becomes degenerate. Model selection and parameter estimation are carried out simultaneously through construction of a pseudo-likelihood function and properly chosen penalty terms. The convexity of the pseudo-likelihood function allows us to develop an efficient algorithm, while the penalty terms generate a low-dimensional latent component and a sparse graphical structure. Desirable theoretical properties are established under suitable regularity conditions. The method is applied to the revised Eysencks personality questionnaire, revealing its usefulness in item analysis. Simulation results are reported that show the new method works well in practical situations.
The noninvasive procedures for neural connectivity are under questioning. Theoretical models sustain that the electromagnetic field registered at external sensors is elicited by currents at neural space. Nevertheless, what we observe at the sensor space is a superposition of projected fields, from the whole gray-matter. This is the reason for a major pitfall of noninvasive Electrophysiology methods: distorted reconstruction of neural activity and its connectivity or leakage. It has been proven that current methods produce incorrect connectomes. Somewhat related to the incorrect connectivity modelling, they disregard either Systems Theory and Bayesian Information Theory. We introduce a new formalism that attains for it, Hidden Gaussian Graphical State-Model (HIGGS). A neural Gaussian Graphical Model (GGM) hidden by the observation equation of Magneto-encephalographic (MEEG) signals. HIGGS is equivalent to a frequency domain Linear State Space Model (LSSM) but with sparse connectivity prior. The mathematical contribution here is the theory for high-dimensional and frequency-domain HIGGS solvers. We demonstrate that HIGGS can attenuate the leakage effect in the most critical case: the distortion EEG signal due to head volume conduction heterogeneities. Its application in EEG is illustrated with retrieved connectivity patterns from human Steady State Visual Evoked Potentials (SSVEP). We provide for the first time confirmatory evidence for noninvasive procedures of neural connectivity: concurrent EEG and Electrocorticography (ECoG) recordings on monkey. Open source packages are freely available online, to reproduce the results presented in this paper and to analyze external MEEG databases.
In this paper, we derive optimal designs for the Rasch Poisson counts model and the Rasch Poisson-Gamma counts model incorporating several binary predictors for the difficulty parameter. To efficiently estimate the regression coefficients of the predictors, locally D-optimal designs are developed. After an introduction to the Rasch Poisson counts model and the Rasch Poisson-Gamma counts model we will specify these models as a particular generalized linear mixed model. Based on this embedding optimal designs for both models including several binary explanatory variables will be presented. Therefore, we will derive conditions on the effect sizes of certain designs to be locally D-optimal. Finally, it is pointed out that the results derived for the Rasch Poisson models can be applied for more general Poisson regression models which should receive more attention in future psychological research.
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