Microbes can affect processes from food production to human health. Such microbes are not isolated, but rather interact with each other and establish connections with their living environments. Understanding these interactions is essential to an understanding of the organization and complex interplay of microbial communities, as well as the structure and dynamics of various ecosystems. A common and essential approach toward this objective involves the inference of microbiome interaction networks. Although network inference methods in other fields have been studied before, applying these methods to estimate microbiome associations based on compositional data will not yield valid results. On the one hand, features of microbiome data such as compositionality, sparsity and high-dimensionality challenge the data normalization and the design of computational methods. On the other hand, several issues like microbial community heterogeneity, external environmental interference and biological concerns also make it more difficult to deal with the network inference. In this paper, we provide a comprehensive review of emerging microbiome interaction network inference methods. According to various assumptions and research targets, estimated networks are divided into four main categories: correlation networks, conditional correlation networks, mixture networks and differential networks. Their scope of applications, advantages and limitations are presented in this review. Since real microbial interactions can be complex and dynamic, no unifying method has captured all the aspects of interest to date. In addition, we discuss the challenges now confronting current microbial associations study and future prospects. Finally, we highlight that the research in microbial network inference requires the joint promotion of statistical computation methods and experimental techniques.
exoplanet is a toolkit for probabilistic modeling of astronomical time series data, with a focus on observations of exoplanets, using PyMC3 (Salvatier et al., 2016). PyMC3 is a flexible and high-performance model-building language and inference engine that scales well to problems with a large number of parameters. exoplanet extends PyMC3s modeling language to support many of the custom functions and probability distributions required when fitting exoplanet datasets or other astronomical time series. While it has been used for other applications, such as the study of stellar variability, the primary purpose of exoplanet is the characterization of exoplanets or multiple star systems using time-series photometry, astrometry, and/or radial velocity. In particular, the typical use case would be to use one or more of these datasets to place constraints on the physical and orbital parameters of the system, such as planet mass or orbital period, while simultaneously taking into account the effects of stellar variability.
The future space-based gravitational wave observatory LISA will consist of a constellation of three spacecraft in a triangular constellation, connected by laser interferometers with 2.5 million-kilometer arms. Among other challenges, the success of the mission strongly depends on the quality of the cancellation of laser frequency noise, whose power lies eight orders of magnitude above the gravitational signal. The standard technique to perform noise removal is time-delay interferometry (TDI). TDI constructs linear combinations of delayed phasemeter measurements tailored to cancel laser noise terms. Previous work has demonstrated the relationship between TDI and principal component analysis (PCA). We build on this idea to develop an extension of TDI based on a model likelihood that directly depends on the phasemeter measurements. Assuming stationary Gaussian noise, we decompose the measurement covariance using PCA in the frequency domain. We obtain a comprehensive and compact framework that we call PCI for principal component interferometry, and show that it provides an optimal description of the LISA data analysis problem.
This paper introduces a statistical model for the arrival times of connection events in a computer network. Edges between nodes in a network can be interpreted and modelled as point processes where events in the process indicate information being sent along that edge. A model of normal behaviour can be constructed for each edge in the network by identifying key network user features such as seasonality and self-exciting behaviour, where events typically arise in bursts at particular times of day. When monitoring the network in real time, unusual patterns of activity could indicate the presence of a malicious actor. Four different models for self-exciting behaviour are introduced and compared using data collected from the Imperial College and Los Alamos National Laboratory computer networks.
This paper considers distributed statistical inference for general symmetric statistics %that encompasses the U-statistics and the M-estimators in the context of massive data where the data can be stored at multiple platforms in different locations. In order to facilitate effective computation and to avoid expensive communication among different platforms, we formulate distributed statistics which can be conducted over smaller data blocks. The statistical properties of the distributed statistics are investigated in terms of the mean square error of estimation and asymptotic distributions with respect to the number of data blocks. In addition, we propose two distributed bootstrap algorithms which are computationally effective and are able to capture the underlying distribution of the distributed statistics. Numerical simulation and real data applications of the proposed approaches are provided to demonstrate the empirical performance.
R. S. Stoica
,S. Liu
,L. J. Liivamagi
.
(2015)
.
"An integrative approach based on probabilistic modelling and statistical inference for morpho-statistical characterization of astronomical data"
.
Radu Stoica
هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا