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Register a new user160 MeV laser-accelerated protons from CH2 nano-targets for proton cancer therapy
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Added by
Bjorn Manuel Hegelich
Publication date
2013
fields
Physics
and research's language is
English
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Proton (and ion) cancer therapy has proven to be an extremely effective even supe-rior method of treatment for some tumors 1-4. A major problem, however, lies in the cost of the particle accelerator facilities; high procurement costs severely limit the availability of ion radiation therapy, with only ~26 centers worldwide. Moreover, high operating costs often prevent economic operation without state subsidies and have led to a shutdown of existing facilities 5,6. Laser-accelerated proton and ion beams have long been thought of as a way out of this dilemma, with the potential to provide the required ion beams at lower cost and smaller facility footprint 7-14. The biggest challenge has been the achievement of sufficient particle energy for therapy, in the 150-250 MeV range for protons 15,16. For the last decade, the maximum exper-imentally observed energy of laser-accelerated protons has remained at ~60 MeV 17. Here we the experimental demonstration of laser-accelerated protons to energies exceeding 150 MeV, reaching the therapy window. This was achieved through a dif-ferent acceleration regime rather than a larger laser, specifically a 150 TW laser with CH2 nano-targets in the relativistically transparent regime 18,19. We also demonstrate a clear scaling law with laser intensity based on analytical theory, computer simulations and experimental validation that will enable design of a pro-totype system spanning the full range of therapeutically desirable energies.
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We report on the first generation of 5.5-7.5 MeV protons by a moderate intensity short-pulse laser (4.5 times 1017 W/cm^2, 50 fsec) interacting with H2O nano-wires (snow) deposited on a Sapphire substrate. In this setup, the laser intensity is locally enhanced by the tip of the snow nano-wire, leading to high spatial gradients. Accordingly, the plasma near the tip is subject to enhanced ponderomotive potential, and confined charge separation is obtained. Electrostatic fields of extremely high intensities are produced over the short scale length, and protons are accelerated to MeV-level energies.
The propagation of ultra intense laser pulses through matter is connected with the generation of strong moving magnetic fields in the propagation channel as well as the formation of a thin ion filament along the axis of the channel. Upon exiting the plasma the magnetic field displaces the electrons at the back of the target, generating a quasistatic electric field that accelerates and collimates ions from the filament. Two-dimensional Particle-in-Cell simulations show that a 1 PW laser pulse tightly focused on a near-critical density target is able to accelerate protons up to an energy of 1.3 GeV. Scaling laws and optimal conditions for proton acceleration are established considering the energy depletion of the laser pulse.
The interaction of ultrashort, high intensity laser pulses with thin foil targets leads to ion acceleration on the target rear surface. To make this ion source useful for applications, it is important to optimize the transfer of energy from the laser into the accelerated ions. One of the most promising ways to achieve this consists in engineering the target front by introducing periodic nanostructures. In this paper, the effect of these structures on ion acceleration is studied analytically and with multi-dimensional particle-in-cell simulations. We assessed the role of the structure shape, size, and the angle of laser incidence for obtaining the efficient energy transfer. Local control of electron trajectories is exploited to maximise the energy delivered into the target. Based on our numerical simulations, we propose a precise range of parameters for fabrication of nanostructured targets, which can increase the energy of the accelerated ions without requiring a higher laser intensity.
A method of generating spin polarized proton beams from a gas jet by using a multi-petawatt laser is put forward. With currently available techniques of producing pre-polarized monatomic gases from photodissociated hydrogen halide molecules and petawatt lasers, proton beams with energy ~ 50 MeV and ~ 80 % polarization are proved to be obtained. Two-stage acceleration and spin dynamics of protons are investigated theoretically and by means of fully self-consistent three dimensional particle-in-cell simulations. Our results predict the dependence of the beam polarization on the intensity of the driving laser pulse. Generation of bright energetic polarized proton beams would open a domain of polarization studies with laser driven accelerators, and have potential application to enable effective detection in explorations of quantum chromodynamics.
In order to realistically simulate the interaction of a femtosecond laser pulse with a nanometre-thick target it is necessary to consider a target preplasma formation due to the nanosecond long amplified-spontaneous-emission pedestal and/or prepulse. The relatively long interaction time dictated that hydrodynamic simulations should be employed to predict the target particles number density distributions prior the arrival of the main laser pulse. By using the output of the hydrodynamic simulations as input into particle-in-cell simulations, a detailed understanding of the complete laser-foil interaction is achieved. Once the laser pulse interacts with the preplasma it deposits a fraction of its energy on the target, before it is either reflected from the critical density surface or transmitted through an underdense plasma channel. A fraction of hot electrons is ejected from the target leaving the foil in a net positive potential, which in turn results in proton and heavy ion ejection. In this work protons reaching ~25 MeV are predicted for a laser of ~40 TW peak power and ~600 MeV are expected from a ~4 PW laser system.
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