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This paper has been withdrawn. Its main conclusions have been published in On dynamics of integrate-and-fi re neural networks with conductance based synapses, arXiv:0709.4370 and http://www.frontiersin.org/computational_neuroscience/10.3389/neuro.10/002.2008/abstract
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Individual locations of many neuronal cell bodies (>10^4) are needed to enable statistically significant measurements of spatial organization within the brain such as nearest-neighbor and microcolumnarity measurements. In this paper, we introduce an Automated Neuron Recognition Algorithm (ANRA) which obtains the (x,y) location of individual neurons within digitized images of Nissl-stained, 30 micron thick, frozen sections of the cerebral cortex of the Rhesus monkey. Identification of neurons within such Nissl-stained sections is inherently difficult due to the variability in neuron staining, the overlap of neurons, the presence of partial or damaged neurons at tissue surfaces, and the presence of non-neuron objects, such as glial cells, blood vessels, and random artifacts. To overcome these challenges and identify neurons, ANRA applies a combination of image segmentation and machine learning. The steps involve active contour segmentation to find outlines of potential neuron cell bodies followed by artificial neural network training using the segmentation properties (size, optical density, gyration, etc.) to distinguish between neuron and non-neuron segmentations. ANRA positively identifies 86[5]% neurons with 15[8]% error (mean[st.dev.]) on a wide range of Nissl-stained images, whereas semi-automatic methods obtain 80[7]%/17[12]%. A further advantage of ANRA is that it affords an unlimited increase in speed from semi-automatic methods, and is computationally efficient, with the ability to recognize ~100 neurons per minute using a standard personal computer. ANRA is amenable to analysis of huge photo-montages of Nissl-stained tissue, thereby opening the door to fast, efficient and quantitative analysis of vast stores of archival material that exist in laboratories and research collections around the world.
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of target genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase as a plastic response. Negative proportionality was observed between the average changes in target and remnant genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. This reciprocity follows the lever principle, which was satisfied throughout the evolutionary course, imposing an evolutionary constraint.
Like ants, some microorganisms are known to leave trails on surfaces to communicate. We explore how trail-mediated self-interaction could affect the behavior of individual microorganisms when diffusive spreading of the trail is negligible on the timescale of the microorganism using a simple phenomenological model for an actively moving particle and a finite-width trail. The effective dynamics of each microorganism takes on the form of a stochastic integral equation with the trail interaction appearing in the form of short-term memory. For moderate coupling strength below an emergent critical value, the dynamics exhibits effective diffusion in both orientation and position after a phase of superdiffusive reorientation. We report experimental verification of a seemingly counterintuitive perpendicular alignment mechanism that emerges from the model.
Wavelet analysis and compression tools are reviewed and different applications to study MHD and plasma turbulence are presented. We introduce the continuous and the orthogonal wavelet transform and detail several statistical diagnostics based on the wavelet coefficients. We then show how to extract coherent structures out of fully developed turbulent flows using wavelet-based denoising. Finally some multiscale numerical simulation schemes using wavelets are described. Several examples for analyzing, compressing and computing one, two and three dimensional turbulent MHD or plasma flows are presented.
Refining a result of Erdos and Mays, we give asymptotic series expansions for the functions $A(x)-C(x)$, the count of $nleq x$ for which every group of order $n$ is abelian (but not all cyclic), and $N(x)-A(x)$, the count of $nleq x$ for which every group of order $n$ is nilpotent (but not all abelian).
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