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Register a new userQuantile Mixed Hidden Markov Models for multivariate longitudinal data
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Added by
Luca Merlo
Publication date
2021
fields
Mathematical Statistics
and research's language is
English
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The identification of factors associated with mental and behavioral disorders in early childhood is critical both for psychopathology research and the support of primary health care practices. Motivated by the Millennium Cohort Study, in this paper we study the effect of a comprehensive set of covariates on childrens emotional and behavioural trajectories in England. To this end, we develop a Quantile Mixed Hidden Markov Model for joint estimation of multiple quantiles in a linear regression setting for multivariate longitudinal data. The novelty of the proposed approach is based on the Multivariate Asymmetric Laplace distribution which allows to jointly estimate the quantiles of the univariate conditional distributions of a multivariate response, accounting for possible correlation between the outcomes. Sources of unobserved heterogeneity and serial dependency due to repeated measures are modeled through the introduction of individual-specific, time-constant random coefficients and time-varying parameters evolving over time with a Markovian structure, respectively. The inferential approach is carried out through the construction of a suitable Expectation-Maximization algorithm without parametric assumptions on the random effects distribution.
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We develop clustering procedures for longitudinal trajectories based on a continuous-time hidden Markov model (CTHMM) and a generalized linear observation model. Specifically in this paper, we carry out finite and infinite mixture model-based clustering for a CTHMM and achieve inference using Markov chain Monte Carlo (MCMC). For a finite mixture model with prior on the number of components, we implement reversible-jump MCMC to facilitate the trans-dimensional move between different number of clusters. For a Dirichlet process mixture model, we utilize restricted Gibbs sampling split-merge proposals to expedite the MCMC algorithm. We employ proposed algorithms to the simulated data as well as a real data example, and the results demonstrate the desired performance of the new sampler.
This paper gives a method for computing distributions associated with patterns in the state sequence of a hidden Markov model, conditional on observing all or part of the observation sequence. Probabilities are computed for very general classes of patterns (competing patterns and generalized later patterns), and thus, the theory includes as special cases results for a large class of problems that have wide application. The unobserved state sequence is assumed to be Markovian with a general order of dependence. An auxiliary Markov chain is associated with the state sequence and is used to simplify the computations. Two examples are given to illustrate the use of the methodology. Whereas the first application is more to illustrate the basic steps in applying the theory, the second is a more detailed application to DNA sequences, and shows that the methods can be adapted to include restrictions related to biological knowledge.
The use of quantiles to obtain insights about multivariate data is addressed. It is argued that incisive insights can be obtained by considering directional quantiles, the quantiles of projections. Directional quantile envelopes are proposed as a way to condense this kind of information; it is demonstrated that they are essentially halfspace (Tukey) depth levels sets, coinciding for elliptic distributions (in particular multivariate normal) with density contours. Relevant questions concerning their indexing, the possibility of the reverse retrieval of directional quantile information, invariance with respect to affine transformations, and approximation/asymptotic properties are studied. It is argued that the analysis in terms of directional quantiles and their envelopes offers a straightforward probabilistic interpretation and thus conveys a concrete quantitative meaning; the directional definition can be adapted to elaborate frameworks, like estimation of extreme quantiles and directional quantile regression, the regression of depth contours on covariates. The latter facilitates the construction of multivariate growth charts---the question that motivated all the development.
We consider the problem of flexible modeling of higher order hidden Markov models when the number of latent states and the nature of the serial dependence, including the true order, are unknown. We propose Bayesian nonparametric methodology based on tensor factorization techniques that can characterize any transition probability with a specified maximal order, allowing automated selection of the important lags and capturing higher order interactions among the lags. Theoretical results provide insights into identifiability of the emission distributions and asymptotic behavior of the posterior. We design efficient Markov chain Monte Carlo algorithms for posterior computation. In simulation experiments, the method vastly outperformed its first and higher order competitors not just in higher order settings, but, remarkably, also in first order cases. Practical utility is illustrated using real world applications.
We discuss Bayesian model uncertainty analysis and forecasting in sequential dynamic modeling of multivariate time series. The perspective is that of a decision-maker with a specific forecasting objective that guides thinking about relevant models. Based on formal Bayesian decision-theoretic reasoning, we develop a time-adaptive approach to exploring, weighting, combining and selecting models that differ in terms of predictive variables included. The adaptivity allows for changes in the sets of favored models over time, and is guided by the specific forecasting goals. A synthetic example illustrates how decision-guided variable selection differs from traditional Bayesian model uncertainty analysis and standard model averaging. An applied study in one motivating application of long-term macroeconomic forecasting highlights the utility of the new approach in terms of improving predictions as well as its ability to identify and interpret different sets of relevant models over time with respect to specific, defined forecasting goals.
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